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Substance Name: A 74932
RN: 148201-60-9
InChIKey: UFBYBJURMXBKFU-UHFFFAOYSA-N

Note

  • A quinobenzoxazine cpd with antitumor activity.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C25-H25-F-N4-O5.Cl-H

Molecular Weight

  • 516.954
 
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Names and Synonyms

Name of Substance

  • A 74932

Synonym

  • A-74932

Systematic Names

  • 3H-Pyrido(3,2,1-k1)phenoxazine-2-carboxylic acid, 6-(2-((2-amino-1-oxopentyl)amino)-1-pyrrolidinyl)-5-fluoro-3-oxo-, monohydrochloride
  • 3H-Pyrido(3,2,1-kl)phenoxazine-2-carboxylic acid, 6-(2-((2-amino-1-oxopentyl)amino)-1-pyrrolidinyl)-5-fluoro-3-oxo-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 148201-60-9

System Generated Number

  • 0148201609

Molecular Formulas

Molecular Formula

  • C25-H25-F-N4-O5.Cl-H

Molecular Formula Fragments

  • C25-H25-F-N4-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C25H25FN4O5.ClH/c1-2-6-16(27)24(32)28-19-9-5-10-29(19)21-15(26)11-13-20-23(21)35-18-8-4-3-7-17(18)30(20)12-14(22(13)31)25(33)34;/h3-4,7-8,11-12,16,19H,2,5-6,9-10,27H2,1H3,(H,28,32)(H,33,34);1H

InChIKey

UFBYBJURMXBKFU-UHFFFAOYSA-N

Smiles

c1cccc2Oc3c(c(cc4c3n(c12)cc(c4=O)C(=O)O)F)N1[C@@H](CCC1)NC([C@@H](CCC)N)=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 59600ug/kg (59.6mg/kg)   Drugs under Experimental and Clinical Research. Vol. 20, Pg. 177, 1994.