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Substance Name: Bismuth subsalicylate [USAN:USP:JAN]
RN: 14882-18-9
UNII: 62TEY51RR1
InChIKey: ZREIPSZUJIFJNP-UHFFFAOYSA-K

Note

  • Bismuth subsalicylate is the active ingredient of Pepto-Bismol and in Kaopectate; used to treat nausea, heartburn, indigestion, upset stomach, diarrhea and other temporary discomforts of the stomach; used with Azoles and other drugs to treat Helicobacter.

Molecular Formula

  • C7-H5-Bi-O4

Molecular Weight

  • 362.092
 

Classification Codes

  • Agricultural Chemical
  • Antacid
  • Anti-Ulcerative
  • Antidiarrheal
  • Antidiarrheals
  • Fungicide, Bactericide, Wood Preservative
  • Gastrointestinal Agents
  • Human Data
  • TSCA Flag P (a Commenced PMN (Premanufacture Notice) Substance)

Names and Synonyms

Name of Substance

  • Bismuth subsalicylate
  • Bismuth subsalicylate [USAN:USP:JAN]

Synonyms

  • 2-Hydroxybenzoic acid bismuth (3+) salt, basic
  • Basic bismuth salicylate
  • Bismogenol tosse inj
  • Bismuth oxysalicylate
  • Bismuth salicylate, basic
  • Bismuth subsalicylate
  • Bismuth, (2-hydroxybenzoato-O(1),O(2))oxo-
  • Bismuth, oxo(salicylato)-
  • Bismuthi subsalicylas
  • Bismutum subsalicylicum
  • CCRIS 4751
  • EC 238-953-1
  • EINECS 238-953-1
  • HSDB 332
  • Kaopectate
  • Pepto-Bismol
  • Salicylic acid basic bismuth salt
  • Salicylic acid, bismuth basic salt
  • Spiromak forte
  • Stabisol
  • Trigastronol
  • UNII-62TEY51RR1
  • Vismut
  • Wismutsalicylat, basisches
  • Wismutsubsalicylat

Systematic Names

  • (2-Hydroxybenzoato-O(sup 1))-oxobismuth
  • 4H-1,3,2-Benzodioxabismin-4-one, 2-hydroxy-
  • Bismuth oxide salicylate
  • Bismuth subsalicylate
  • Bismuth, (2-hydroxybenzoato-O1,O2)oxo- (9CI)
  • Bismuth, oxo(salicylato)-

Mixture Name

  • Helidac

Registry Numbers

CAS Registry Number

  • 14882-18-9

FDA UNII

  • 62TEY51RR1

Other Registry Numbers

  • 55200-42-5
  • 56029-89-1
  • 61529-49-5
  • 8045-18-9
  • 87-27-4

System Generated Number

  • 0014882189

Structure Descriptors

InChI

1S/C7H6O3.Bi.H2O/c8-6-4-2-1-3-5(6)7(9)10;;/h1-4,8H,(H,9,10);;1H2/q;+3;/p-3

InChIKey

ZREIPSZUJIFJNP-UHFFFAOYSA-K

Smiles

c12c(O[Bi](O)OC1=O)cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo intramuscular 60mg/kg/26W-I (60mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" American Journal of Clinical Pathology. Vol. 14, Pg. 392, 1944.
man TDLo intramuscular 17mg/kg/5W-I (17mg/kg) GASTROINTESTINAL: OTHER CHANGES American Journal of Syphilis, Gonorrhea and Venereal Diseases. Vol. 26, Pg. 84, 1942.
women TDLo intramuscular 14480ug/kg/9D (14.48mg/kg)   Archives of Dermatology and Syphilology. Vol. 41, Pg. 1076, 1940.
women TDLo intramuscular 14480ug/kg/9D (14.48mg/kg) MUSCULOSKELETAL: JOINTS

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
Archives of Dermatology and Syphilology. Vol. 41, Pg. 1076, 1940.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.460 (none)   EST
Water Solubility 44 mg/L 25 EST
Vapor Pressure 6.07E-06 mm Hg 25 EST
Atmospheric OH Rate Constant 2.09E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.