Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Oxymetazoline [INN:BAN]
RN: 1491-59-4
UNII: 8VLN5B44ZY
InChIKey: WYWIFABBXFUGLM-UHFFFAOYSA-N

Note

  • A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)

Molecular Formula

  • C16-H24-N2-O

Molecular Weight

  • 260.3786
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Agonists
  • Adrenergic alpha-Agonists
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Nasal Decongestants
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Respiratory System Agents
  • Sympathomimetics
  • Vasoconstrictor Agents

Names and Synonyms

Name of Substance

  • Oxymetazoline
  • Oxymetazoline [INN:BAN]

MeSH Heading

  • Oxymetazoline

Synonyms

  • 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline
  • 5-23-11-00424 (Beilstein Handbook Reference)
  • 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol
  • BRN 0886303
  • EINECS 216-079-1
  • H 990
  • Hazol
  • HSDB 3143
  • Iliadin
  • Nafrine
  • Navisin
  • Nezeril
  • Oximetazolina
  • Oximetazolina [INN-Spanish]
  • Oximetazolinum
  • Oxylazine
  • Oxymetazoline
  • Oxymetazolinum
  • Oxymetazolinum [INN-Latin]
  • Oxymethazoline
  • Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-
  • Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-
  • Rhinofrenol
  • Sinerol
  • UNII-8VLN5B44ZY

Systematic Names

  • Oxymetazoline
  • Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl-
  • Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-

Registry Numbers

CAS Registry Number

  • 1491-59-4

FDA UNII

  • 8VLN5B44ZY

System Generated Number

  • 0001491594

Structure Descriptors

InChI

1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)

InChIKey

WYWIFABBXFUGLM-UHFFFAOYSA-N

Smiles

Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 2700ug/kg (2.7mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 74, 1967.
rat LD50 oral 800ug/kg (0.8mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 subcutaneous 1100ug/kg (1.1mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 182 deg C   EXP
log P (octanol-water) 4.870 (none)   EST
Atmospheric OH Rate Constant 9.72E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.