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Substance Name: Heparin-binding egf-like growth factor
RN: 149176-25-0


  • An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.
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Names and Synonyms

Name of Substance

  • Heparin-binding egf-like growth factor

MeSH Heading

  • Heparin-binding EGF-like Growth Factor


  • HB-Egf

Systematic Name

  • Peptide, (Arg-Val-Xaa-Leu-Ser-Ser-Lys-Pro-Gln-Ala-Leu-Ala-Xaa-Pro-Asn-Lys-Glu-Glu-His-Gly-Lys-Arg-Lys-Lys-Lys-Gly-Lys-Gly-Leu-Gly-Lys-Lys-Arg-Asp-Pro-Cys-Leu-Arg-Lys-Tyr-Lys-Asp)

Registry Numbers

CAS Registry Number

  • 149176-25-0

System Generated Number

  • 0149176250