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Substance Name: Glybuzole [INN:JAN]
RN: 1492-02-0
UNII: 1DJ2B68M2C
InChIKey: NMWQEPCLNXHPDX-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C12-H15-N3-O2-S2

Molecular Weight

  • 297.4015
 
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Names and Synonyms

Name of Substance

  • Glybuzole
  • Glybuzole [INN:JAN]

Synonyms

  • 2-Benzenesulfonamido-5-tert-butyl-1,3,4-thiadiazole
  • 2-Benzenesulfonamido-5-tertiobutyl-1-thia-3,4-diazole
  • AN 1324
  • BRN 1082473
  • Desaglybuzole
  • EINECS 216-081-2
  • Glibuzol
  • Glibuzol [INN-Spanish]
  • Gludiase
  • Glybuzole
  • Glybuzolum
  • Glybuzolum [INN-Latin]
  • N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
  • RP 7891
  • TH-1395
  • UNII-1DJ2B68M2C

Systematic Names

  • Benzenesulfonamide, N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-
  • Glybuzole
  • N-(5-tert-Butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

Registry Numbers

CAS Registry Number

  • 1492-02-0

FDA UNII

  • 1DJ2B68M2C

System Generated Number

  • 0001492020

Structure Descriptors

InChI

1S/C12H15N3O2S2/c1-12(2,3)10-13-14-11(18-10)15-19(16,17)9-7-5-4-6-8-9/h4-8H,1-3H3,(H,14,15)

InChIKey

NMWQEPCLNXHPDX-UHFFFAOYSA-N

Smiles

n1c(NS(=O)(=O)c2ccccc2)sc(C(C)(C)C)n1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 235mg/kg (235mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
mouse LD50 intravenous 193mg/kg (193mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
mouse LD50 oral 550mg/kg (550mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

ENDOCRINE: HYPOGLYCEMIA
Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 131, 1969.
mouse LD50 subcutaneous 248mg/kg (248mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rabbit LD50 intraperitoneal 300mg/kg (300mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rabbit LD50 intravenous 118mg/kg (118mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rabbit LD50 oral 967mg/kg (967mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rat LD50 intraperitoneal 219mg/kg (219mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rat LD50 oral 500mg/kg (500mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.
rat LD50 subcutaneous 310mg/kg (310mg/kg)   Yamaguchi Igaku. Yamaguchi Medicine. Vol. 18, Pg. 21, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 163 deg C   EXP
log P (octanol-water) 2.690 (none)   EST
Atmospheric OH Rate Constant 1.62E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.