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Substance Name: Leucovorin calcium [USP]
RN: 1492-18-8
UNII: RPR1R4C0P4
InChIKey: KVUAALJSMIVURS-ZEDZUCNESA-L
Note
- The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid.
Molecular Formulas
- C20-H21-Ca-N7-O7
- C20-H21-N7-O7.Ca
- C20-H23-N7-O7.Ca
Molecular Weight
- 511.5059
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Anemic (Folate Deficiency)
- Antidote (to Folic Acid Antagonists)
- Drug / Therapeutic Agent
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Names and Synonyms
Name of Substance
- Calcium folinate [INN]
- Leucovorin calcium [USP]
Synonyms
- (+)-L-Folinic acid, calcium salt
- Calcii folinas
- Calcii folinas [INN-Latin]
- Calcium 5-formyltetrahydrofolate
- Calcium citrovorum factor
- Calcium folinate
- Calcium L-folinate
- Calcium leucovorin
- Calcium N-(p-((((6RS)-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1)
- EINECS 216-082-8
- Folidan
- Folinate de calcium
- Folinate de calcium [INN-French]
- Folinate-SF Calcium
- Folinato calcico
- Folinato calcico [INN-Spanish]
- Folinic acid calcium salt
- Folinic acid-SF, calcium salt
- Lederfoline
- Leucovorin calcium
- Leucovorin calcium preservative free
- Leucovorin calcium salt
- NSC 3590
- Rescuvolin
- UNII-RPR1R4C0P4
- Wellcovorin
Systematic Names
- Calcium folinate
- Glutamic acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1), L-
- L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1)
Registry Numbers
CAS Registry Number
- 1492-18-8
FDA UNII
- RPR1R4C0P4
Other Registry Numbers
- 1236362-90-5
- 30771-29-0
- 6035-86-5
- 6209-45-6
Related Registry Number
- 58-05-9 (Parent)
System Generated Number
- 0001492188
Molecular Formulas
Molecular Formulas
- C20-H21-Ca-N7-O7
- C20-H21-N7-O7.Ca
- C20-H23-N7-O7.Ca
Molecular Formula Fragments
- C20-H21-N7-O7
- C20-H23-N7-O7
- Ca
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1InChIKey
KVUAALJSMIVURS-ZEDZUCNESA-LSmiles
[Ca+2].NC1=NC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 1036mg/kg (1036mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992. | |
mouse | LD50 | intravenous | 732mg/kg (732mg/kg) | Drugs in Japan Vol. 6, Pg. 910, 1982. | |
mouse | LD50 | oral | > 7gm/kg (7000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992. | |
rat | LD50 | intraperitoneal | 1063mg/kg (1063mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992. | |
rat | LD50 | oral | > 8gm/kg (8000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992. |