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Substance Name: Leucovorin calcium [USP]
RN: 1492-18-8
UNII: RPR1R4C0P4
InChIKey: KVUAALJSMIVURS-ZEDZUCNESA-L

Note

  • The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid.

Molecular Formulas

  • C20-H21-Ca-N7-O7
  • C20-H21-N7-O7.Ca
  • C20-H23-N7-O7.Ca

Molecular Weight

  • 511.5059
 

Classification Codes

  • Anti-Anemic (Folate Deficiency)
  • Antidote (to Folic Acid Antagonists)
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Calcium folinate [INN]
  • Leucovorin calcium [USP]

Synonyms

  • (+)-L-Folinic acid, calcium salt
  • Calcii folinas
  • Calcii folinas [INN-Latin]
  • Calcium 5-formyltetrahydrofolate
  • Calcium citrovorum factor
  • Calcium folinate
  • Calcium L-folinate
  • Calcium leucovorin
  • Calcium N-(p-((((6RS)-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate (1:1)
  • EINECS 216-082-8
  • Folidan
  • Folinate de calcium
  • Folinate de calcium [INN-French]
  • Folinate-SF Calcium
  • Folinato calcico
  • Folinato calcico [INN-Spanish]
  • Folinic acid calcium salt
  • Folinic acid-SF, calcium salt
  • Lederfoline
  • Leucovorin calcium
  • Leucovorin calcium preservative free
  • Leucovorin calcium salt
  • NSC 3590
  • Rescuvolin
  • UNII-RPR1R4C0P4
  • Wellcovorin

Systematic Names

  • Calcium folinate
  • Glutamic acid, N-(p-(((2-amino-5-formyl-5,6,7,8-tetrahydro-3-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1), L-
  • L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, calcium salt (1:1)

Registry Numbers

CAS Registry Number

  • 1492-18-8

FDA UNII

  • RPR1R4C0P4

Other Registry Numbers

  • 1236362-90-5
  • 30771-29-0
  • 6035-86-5
  • 6209-45-6

Related Registry Number

  • 58-05-9 (Parent)

System Generated Number

  • 0001492188

Molecular Formulas

Molecular Formulas

  • C20-H21-Ca-N7-O7
  • C20-H21-N7-O7.Ca
  • C20-H23-N7-O7.Ca

Molecular Formula Fragments

  • C20-H21-N7-O7
  • C20-H23-N7-O7
  • Ca
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChIKey

KVUAALJSMIVURS-ZEDZUCNESA-L

Smiles

[Ca+2].NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])N2C=O)N1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1036mg/kg (1036mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
mouse LD50 intravenous 732mg/kg (732mg/kg)   Drugs in Japan Vol. 6, Pg. 910, 1982.
mouse LD50 oral > 7gm/kg (7000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 intraperitoneal 1063mg/kg (1063mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 oral > 8gm/kg (8000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.