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Substance Name: Fasciclin IV
RN: 149223-89-2


  • A family of proteins that mediate AXONAL GUIDANCE. Semaphorins act as repulsive cues for neuronal GROWTH CONES and bind to receptors on their filopodia. At least 20 different molecules have been described and divided into eight classes based on domain organization and species of origin. Classes 1 and 2 are invertebrate, classes 3-7 are vertebrate, and class V are viral. Semaphorins may be secreted (classes 2, 3, and V), transmembrane (classes 1, 4, 5, and 6), or membrane-anchored (class 7). All semaphorins possess a common 500-amino acid extracellular domain which is critical for receptor binding and specificity, and is also found in plexins and scatter factor receptors. Their C termini are class-specific and may contain additional sequence motifs.
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Names and Synonyms

Name of Substance

  • Fasciclin IV

MeSH Heading

  • Semaphorins


  • Fas IV
  • Fasciclin IV (grasshopper embryo gene Fas4)
  • Sema 1
  • Semaphorin 1
  • Semaphorin I (grasshopper embryo gene Fas4)

Systematic Name

  • Fasciclin IV (grasshopper embryo precursor reduced)

Registry Numbers

CAS Registry Number

  • 149223-89-2

System Generated Number

  • 0149223892