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Substance Name: UR 8225
RN: 149455-36-7
InChIKey: PJCGOKFHROWGBX-UHFFFAOYSA-N

Note

  • Potassium channel activator with cardiovascular activity.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H14-N2-O2

Molecular Weight

  • 290.321
 
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Names and Synonyms

Name of Substance

  • UR 8225

Synonyms

  • 1,2-Dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-1-oxonaphthalene-6-carbonitrile
  • 5,6-Dihydro-6,6-dimethyl-5-oxo-8-(2-oxo-1(2H)-pyridinyl)-2-naphthalenecarbonitrile
  • UR 8225

Systematic Name

  • 2-Naphthalenecarbonitrile, 5,6-dihydro-6,6-dimethyl-5-oxo-8-(2-oxo-1(2H)-pyridinyl)-

Registry Numbers

CAS Registry Number

  • 149455-36-7

System Generated Number

  • 0149455367

Structure Descriptors

InChI

1S/C18H14N2O2/c1-18(2)10-15(20-8-4-3-5-16(20)21)14-9-12(11-19)6-7-13(14)17(18)22/h3-10H,1-2H3

InChIKey

PJCGOKFHROWGBX-UHFFFAOYSA-N

Smiles

c1c(ccc2C(C(C=C(c12)n1ccccc1=O)(C)C)=O)C#N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 800mg/kg (800mg/kg)   Cardiovascular Drug Reviews. Vol. 14, Pg. 256, 1996.
rat LD50 oral > 100mg/kg (100mg/kg)   Cardiovascular Drug Reviews. Vol. 14, Pg. 256, 1996.