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Substance Name: Vorinostat [USAN:INN]
RN: 149647-78-9
UNII: 58IFB293JI
InChIKey: WAEXFXRVDQXREF-UHFFFAOYSA-N

Notes

  • A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.
  • Inhibits histone deacetylase I & 3.

Molecular Formula

  • C14-H20-N2-O3

Molecular Weight

  • 264.323
 

Classification Codes

  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • Antineoplastic, Histone Deacetylase Inhibitor
  • Antitumor Agent
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitor
  • Histone Deacetylase Inhibitors

Names and Synonyms

Name of Substance

  • Vorinostat
  • Vorinostat [USAN:INN]

MeSH Heading

  • Vorinostat

Synonyms

  • CCRIS 8456
  • HSDB 7930
  • M344
  • MK 0683
  • MK-0683
  • MK0683
  • N-Hydroxy-N'-phenyloctanediamide
  • NSC 701852
  • NSC 748799
  • NSC 759852
  • SAHA
  • SAHA cpd
  • Suberanilohydroxamic acid
  • Suberoylanilide hydroxamic acid
  • UNII-58IFB293JI
  • VOR
  • Vorinostat
  • Zolinza

Systematic Name

  • Octanediamide, N-hydroxy-N'-phenyl-

Registry Numbers

CAS Registry Number

  • 149647-78-9

FDA UNII

  • 58IFB293JI

System Generated Number

  • 0149647789

Structure Descriptors

InChI

InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)

InChIKey

WAEXFXRVDQXREF-UHFFFAOYSA-N

Smiles

ONC(=O)CCCCCCC(=O)Nc1ccccc1