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Substance Name: Emivirine [USAN:INN]
RN: 149950-60-7
UNII: X87G8IX72O
InChIKey: MLILORUFDVLTSP-UHFFFAOYSA-N

Note

  • A non-nucleoside inhibitor of HIV-1 reverse transcriptase.

Molecular Formula

  • C17-H22-N2-O3

Molecular Weight

  • 302.3718
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral
  • Antiviral Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Non-Nucleoside Reverse Transcriptase Inhibitor
  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors
  • Treatment of HIV-1 Infections (Non-Nucleoside Reverse Transcriptase Inhibitor)
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Names and Synonyms

Name of Substance

  • Emivirine
  • Emivirine [USAN:INN]

Synonyms

  • 1-(Ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)-2,4(1H,3H)-pyrimidinedione
  • 1EtOMe6Bz5i-Pr-U
  • 2,4(1H,3H)-Pyrimidinedione, 1-(ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)-
  • 6-Benzyl-1-(ethoxymethyl)-5-isopropyluracil
  • Coactinon
  • DRG-0302
  • Emivirine
  • I-EBU
  • MKC 442
  • MKC-442
  • UNII-X87G8IX72O

Systematic Name

  • 2,4(1H,3H)-Pyrimidinedione, 1-(ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)-

Registry Numbers

CAS Registry Number

  • 149950-60-7

FDA UNII

  • X87G8IX72O

System Generated Number

  • 0149950607

Structure Descriptors

InChI

1S/C17H22N2O3/c1-4-22-11-19-14(10-13-8-6-5-7-9-13)15(12(2)3)16(20)18-17(19)21/h5-9,12H,4,10-11H2,1-3H3,(H,18,20,21)

InChIKey

MLILORUFDVLTSP-UHFFFAOYSA-N

Smiles

CCOCn1c(c(c(=O)[nH]c1=O)C(C)C)Cc2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LDLo oral 2500mg/kg (2500mg/kg)   Antimicrobial Agents and Chemotherapy. Vol. 44, Pg. 123, 2000.