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Substance Name: Rimantadine hydrochloride [USAN:USP]
RN: 1501-84-4
UNII: JEI07OOS8Y
InChIKey: OZBDFBJXRJWNAV-UHFFFAOYSA-N

Note

  • An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.

    See CDC 2009 H1N1 Flu (Swine Flu) Antiviral Drugs at CDC Antiviral Drugs

Molecular Formula

  • C12-H21-N.Cl-H

Molecular Weight

  • 215.766
 

Classification Codes

  • Antiviral
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Rimantadine hydrochloride [USAN:USP]

Synonyms

  • 1-(1-Aminoethyl)adamantane hydrochloride
  • Adamantane, 1-(1-aminoethyl)-, hydrochloride
  • alpha-Methyl-1-adamantanemethylamine hydrochloride
  • alpha-Methyltricyclo(3.3.1.1(sup 3,7))decane-1-methanamine hydrochloride
  • EXP 126
  • Flumadine
  • JP 61
  • Meradane
  • NSC 206764
  • Rimantadine HCl
  • Rimantadine hydrochloride
  • Tricyclo(3.3.1.1(sup 3,7))-decane-1-methanamine, alpha-methyl-, hydrochloride
  • UNII-JEI07OOS8Y

Systematic Names

  • 1-Adamantanemethylamine, alpha-methyl-, hydrochloride
  • Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-, hydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 1501-84-4

FDA UNII

  • JEI07OOS8Y

System Generated Number

  • 0001501844

Molecular Formulas

Molecular Formula

  • C12-H21-N.Cl-H

Molecular Formula Fragments

  • C12-H21-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H

InChIKey

OZBDFBJXRJWNAV-UHFFFAOYSA-N

Smiles

C1C2CC3CC1CC(C3)(C2)[C@@H](N)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 135mg/kg (135mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA
Pharmaceutical Chemistry Journal Vol. 11, Pg. 798, 1977.
rat LD50 oral 640mg/kg (640mg/kg)   Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. Vol. 28(9), Pg. 23, 1982.