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Substance Name: Rimantadine hydrochloride [USAN:USP]
RN: 1501-84-4
UNII: JEI07OOS8Y
InChIKey: OZBDFBJXRJWNAV-UHFFFAOYSA-N

Notes

  • An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.

    See CDC 2009 H1N1 Flu (Swine Flu) Antiviral Drugs at CDC Antiviral Drugs
  • See CDC 2009 H1N1 Flu (Swine Flu) Antiviral Drugs at CDC Antiviral Drugs

Molecular Formula

  • C12-H21-N.Cl-H

Molecular Weight

  • 215.766
 

Classification Codes

  • Antiviral
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Rimantadine hydrochloride [USAN:USP]

Synonyms

  • 1-(1-Aminoethyl)adamantane hydrochloride
  • Adamantane, 1-(1-aminoethyl)-, hydrochloride
  • alpha-Methyl-1-adamantanemethylamine hydrochloride
  • alpha-Methyltricyclo(3.3.1.1(sup 3,7))decane-1-methanamine hydrochloride
  • EXP 126
  • Flumadine
  • JP 61
  • Meradane
  • NSC 206764
  • Rimantadine HCl
  • Rimantadine hydrochloride
  • Tricyclo(3.3.1.1(sup 3,7))-decane-1-methanamine, alpha-methyl-, hydrochloride
  • UNII-JEI07OOS8Y

Systematic Names

  • 1-Adamantanemethylamine, alpha-methyl-, hydrochloride
  • Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 1501-84-4

FDA UNII

  • JEI07OOS8Y

System Generated Number

  • 0001501844

Molecular Formulas

Molecular Formula

  • C12-H21-N.Cl-H

Molecular Formula Fragments

  • C12-H21-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H

InChIKey

OZBDFBJXRJWNAV-UHFFFAOYSA-N

Smiles

Cl.CC(N)C12CC3CC(CC(C3)C1)C2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 135mg/kg (135mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA
Pharmaceutical Chemistry Journal Vol. 11, Pg. 798, 1977.
rat LD50 oral 640mg/kg (640mg/kg)   Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. Vol. 28(9), Pg. 23, 1982.