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Substance Name: Naftypramide [INN]
RN: 1505-95-9
UNII: 7A7HW5472J
InChIKey: XXFVRXJPEIBBEZ-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H26-N2-O

Molecular Weight

  • 298.4274
 
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Names and Synonyms

Name of Substance

  • Naftypramide [INN]

Synonyms

  • 1-Naphthylacetamide, alpha-isopropyl-alpha-(2-dimethylaminoethyl)-
  • 4-Dimethylamino-2-isopropyl-2-(1-naphtyl)butyramid
  • alpha-Isopropyl-alpha-(2-(dimethylamino)ethyl)-1-naphthaleneacetamide
  • alpha-Isopropyl-alpha-(2-dimethylaminoethyl)-1-naphthacetamide
  • alpha-Isopropyl-alpha-(2-dimethylaminoethyl)-1-naphthylacetamide
  • BRN 2815141
  • DA 992
  • DA-992
  • Naftipramida
  • Naftipramida [INN-Spanish]
  • Naftipramide
  • Naftipramide [DCIT]
  • Naftypramide
  • Naftypramidum
  • Naftypramidum [INN-Latin]
  • Naphthipramide
  • Naphthypramide
  • UNII-7A7HW5472J

Systematic Names

  • 1-Naphthaleneacetamide, alpha-(2-(dimethylamino)ethyl)-alpha-isopropyl-
  • alpha-Isopropyl-alpha-(2-(dimethylamino)ethyl)-1-naphthaleneacetamide

Registry Numbers

CAS Registry Number

  • 1505-95-9

FDA UNII

  • 7A7HW5472J

System Generated Number

  • 0001505959

Structure Descriptors

InChI

1S/C19H26N2O/c1-14(2)19(18(20)22,12-13-21(3)4)17-11-7-9-15-8-5-6-10-16(15)17/h5-11,14H,12-13H2,1-4H3,(H2,20,22)

InChIKey

XXFVRXJPEIBBEZ-UHFFFAOYSA-N

Smiles

CC(C)C(CCN(C)C)(c1cccc2c1cccc2)C(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral > 500mg/kg (500mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 356, 1968.
mouse LD50 intravenous 72mg/kg (72mg/kg)   Experientia. Vol. 20, Pg. 457, 1964.
mouse LD50 oral 1086mg/kg (1086mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 162, Pg. 378, 1966.
mouse LDLo intraperitoneal 250mg/kg (250mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Journal of Medicinal Chemistry. Vol. 8, Pg. 594, 1965.
rat LD50 intraperitoneal 269mg/kg (269mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 162, Pg. 378, 1966.
rat LD50 oral 1030mg/kg (1030mg/kg)   Journal of Medicinal Chemistry. Vol. 16, Pg. 720, 1973.