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Substance Name: Tolvaptan [USAN:INN:BAN]
RN: 150683-30-0
UNII: 21G72T1950
InChIKey: GYHCTFXIZSNGJT-UHFFFAOYSA-N

Note

  • DailyMed: Tolvaptan is a selective vasopressin V2-receptor antagonist with an affinity for the V2-receptor that is 1.8 times that of native arginine vasopressin (AVP).

Molecular Formula

  • C26-H25-Cl-N2-O3

Molecular Weight

  • 448.9475
 

Classification Codes

  • Antidiuretic Hormone Receptor Antagonists
  • Natriuretic Agents
  • Treatment of Congestive Heart Failure and Hyponatremia (Vasopressin V2 Receptor Antagonist)
  • Vasopressin V2 Receptor Antagonist

Names and Synonyms

Name of Substance

  • Tolvaptan
  • Tolvaptan [USAN:INN:BAN]

Synonyms

  • (+-)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl) carbonyl)-o-tolu-m-toluidide
  • 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
  • Benzamide, N-(4-((7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-3-methylphenyl)-2-methyl-
  • HSDB 8196
  • OPC 41061
  • OPC-41061
  • Samsca
  • Tolvaptan
  • UNII-21G72T1950

Systematic Name

  • (+-)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-o-tolu-m-toluidide

Registry Numbers

CAS Registry Number

  • 150683-30-0

FDA UNII

  • 21G72T1950

System Generated Number

  • 0150683300

Structure Descriptors

InChI

1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

InChIKey

GYHCTFXIZSNGJT-UHFFFAOYSA-N

Smiles

Cc1ccccc1C(=O)Nc2ccc(C(=O)N3CCCC(O)c4cc(Cl)ccc34)c(C)c2