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Substance Name: Mitopodozide [INN:BAN]
RN: 1508-45-8
UNII: 6QYI7Y8OBO
InChIKey: CPTIBDHUFVHUJK-NZYDNVMFSA-N

Note

  • An ethylhydrazide derivative of podophyllic acid.

Molecular Formula

  • C24-H30-N2-O8

Molecular Weight

  • 474.507
 

Classification Codes

  • Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Mitopodozide [INN:BAN]

Synonyms

  • AI3-51435
  • EINECS 216-138-1
  • IND 379
  • Mitopodozide
  • Mitopodozido
  • Mitopodozido [INN-Spanish]
  • Mitopodozidum
  • Mitopodozidum [INN-Latin]
  • N'-Ethylpodophyllohydrazid
  • NSC 72274
  • NSC-72274
  • Podophyllic acid ethylhydrazide
  • Podophyllic acid, 2-ethyl-hydrazide
  • Podophyllinic acid 2-ethylhydrazide
  • Podophyllinic acid ethylhydrazide
  • Podophyllinsaeure-aethylhydrazid
  • Podophyllinsaeure-aethylhydrazid [German]
  • Proresid
  • Proreside
  • Proresipar
  • SP-I (Pharmaceutical)
  • SP-I 77
  • SPI 77
  • SPI-77
  • UNII-6QYI7Y8OBO

Systematic Names

  • Mitopodozide
  • Naphtho(2,3-d)-1,3-dioxole-6-carboxylic acid, 5,6,7,8-tetrahydro-8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-, 2-ethylhydrazide, (5R-(5alpha,6alpha,7beta,8alpha))- (9CI)
  • Podophyllic acid 2-ethylhydrazide

Registry Numbers

CAS Registry Number

  • 1508-45-8

FDA UNII

  • 6QYI7Y8OBO

Other Registry Numbers

  • 1904-80-9
  • 7614-31-5
  • 8059-98-1

System Generated Number

  • 0001508458

Structure Descriptors

InChI

1S/C24H30N2O8/c1-5-25-26-24(29)21-15(10-27)22(28)14-9-17-16(33-11-34-17)8-13(14)20(21)12-6-18(30-2)23(32-4)19(7-12)31-3/h6-9,15,20-22,25,27-28H,5,10-11H2,1-4H3,(H,26,29)/t15-,20+,21-,22-/m0/s1

InChIKey

CPTIBDHUFVHUJK-NZYDNVMFSA-N

Smiles

CCNNC(=O)[C@H]1[C@@H]([C@H](c2cc3c(cc2[C@H]1c4cc(c(c(c4)OC)OC)OC)OCO3)O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 intravenous 140mg/kg (140mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970.
rat LD50 unreported 140mg/kg (140mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 363, 1970.