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Substance Name: Tropicamide [USAN:USP:INN:BAN:JAN]
RN: 1508-75-4
UNII: N0A3Z5XTC6
InChIKey: BGDKAVGWHJFAGW-UHFFFAOYSA-N

Note

  • One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.

Molecular Formula

  • C17-H20-N2-O2

Molecular Weight

  • 284.357
 

Classification Codes

  • Anticholinergic (Ophthalmic)
  • Autonomic Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Drug / Therapeutic Agent
  • Muscarinic Antagonists
  • Mydriatics
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
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Names and Synonyms

Name of Substance

  • Tropicamide
  • Tropicamide [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Tropicamide

Synonyms

  • (+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
  • 5-22-09-00359 (Beilstein Handbook Reference)
  • Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (+-)-
  • Bistropamide
  • BRN 0285563
  • EINECS 216-140-2
  • Epitromina
  • Hydracrylamide, N-ethyl-2-phenyl-N-(4-pyridylmethyl)-
  • Minims tropicamide
  • Mydriacyl
  • Mydriafair
  • Mydriaticum
  • Mydrum
  • N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide
  • N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide
  • N-Ethyl-N-(4-pyridylmethyl)tropamid
  • Ro 1-7683
  • Tropicacyl
  • Tropicamida
  • Tropicamida [INN-Spanish]
  • Tropicamide
  • Tropicamidum
  • Tropicamidum [INN-Latin]
  • Tropikamid
  • Tropimil
  • UNII-N0A3Z5XTC6
  • Visumidriatic

Systematic Names

  • Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-
  • Tropicamide

Mixture Name

  • Paremyd

Registry Numbers

CAS Registry Number

  • 1508-75-4

FDA UNII

  • N0A3Z5XTC6

System Generated Number

  • 0001508754

Structure Descriptors

InChI

1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3

InChIKey

BGDKAVGWHJFAGW-UHFFFAOYSA-N

Smiles

CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 695mg/kg (695mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
mouse LD50 oral 565mg/kg (565mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
mouse LD50 subcutaneous 665mg/kg (665mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
rat LD50 intraperitoneal 1210mg/kg (1210mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
rat LD50 oral 865mg/kg (865mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.
rat LD50 subcutaneous 872mg/kg (872mg/kg)   Drugs in Japan Vol. -, Pg. 760, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 96.5 deg C   EXP
log P (octanol-water) 1.190 (none)   EST
Atmospheric OH Rate Constant 4.31E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.