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Substance Name: Chlorphentermine hydrochloride [USAN]
RN: 151-06-4
UNII: RL11HOJ7DM
InChIKey: WEJDYJKJPUPMLH-UHFFFAOYSA-N

Note

  • A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of DEXTROAMPHETAMINE. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)

Molecular Formula

  • C10-H14-Cl-N.Cl-H

Molecular Weight

  • 220.1415
 

Classification Codes

Classification Codes

  • Anorexic
  • Drug / Therapeutic Agent
  • Reproductive Effect

Superlist Classification Code

  • DEA Schedule III
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Names and Synonyms

Name of Substance

  • Chlorphentermine hydrochloride [USAN]

Synonyms

  • 1-(p-Chlorophenyl)-2-methyl-2-aminopropane hydrochloride
  • 4-Chloro-alpha,alpha-dimethylphenethylamine hydrochloride
  • alpha,alpha-Dimethyl-p-chlorophenethylamine hydrochloride
  • Apsedon
  • Avicol
  • Avicol, pharmaceutical (VAN)
  • Avipron
  • Benzeneethanamine, 4-chloro-alpha,alpha-dimethyl-, hydrochloride
  • Chlorophen
  • Chlorophentermine hydrochloride
  • Chlorphentermine HCl
  • Chlorphentermine hydrochloride
  • Chlorphenterminum hydrochloride
  • Clomina
  • Copene
  • Desopimon
  • Dezopimon
  • EINECS 205-782-9
  • Lucofen
  • Lucofene
  • Lukofen hydrochloride
  • Nilgana
  • NSC 76098
  • NSC-76098
  • p-Chloro-alpha,alpha-dimethylphenethylamine hydrochloride
  • p-Chlorphentermine hydrochloride
  • Pre-Sate
  • S 62
  • S 62-2
  • S-62
  • Teramine hydrochloride
  • UNII-RL11HOJ7DM
  • W 2426
  • WX 2426

Systematic Names

  • Benzeneethanamine, 4-chloro-alpha,alpha-dimethyl-, hydrochloride
  • Chlorphentermine hydrochloride
  • Phenethylamine, p-chloro-alpha,alpha-dimethyl-, hydrochloride

Superlist Names

  • Chlorphentermine
  • DEA No. 1645
  • Lucofen
  • Pre-Sate

Registry Numbers

CAS Registry Number

  • 151-06-4

FDA UNII

  • RL11HOJ7DM

Other Registry Number

  • 53529-57-0

System Generated Number

  • 0000151064

Molecular Formulas

Molecular Formula

  • C10-H14-Cl-N.Cl-H

Molecular Formula Fragments

  • C10-H14-Cl-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C10H14ClN.ClH/c1-10(2,12)7-8-3-5-9(11)6-4-8;/h3-6H,7,12H2,1-2H3;1H

InChIKey

WEJDYJKJPUPMLH-UHFFFAOYSA-N

Smiles

c1c(ccc(c1)CC(C)(C)N)Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 88mg/kg (88mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Chimica Therapeutica. Vol. 5, Pg. 247, 1970.
mouse LD50 intravenous 55mg/kg (55mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 137, Pg. 365, 1962.
mouse LD50 oral 225mg/kg (225mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 711, 1963.
mouse LD50 subcutaneous 225mg/kg (225mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Acta Pharmaceutica Suecica. Vol. 4, Pg. 37, 1967.
rat LD50 intraperitoneal 144mg/kg (144mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL) Acta Pharmacologica et Toxicologica. Vol. 17, Pg. 121, 1960.
rat LD50 oral 150mg/kg (150mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Chimica Therapeutica. Vol. 5, Pg. 247, 1970.