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Substance Name: Halothane [USP:INN:BAN:JAN]
RN: 151-67-7
UNII: UQT9G45D1P
InChIKey: BCQZXOMGPXTTIC-UHFFFAOYSA-N
Note
- A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Molecular Formula
- C2-H-Br-Cl-F3
Molecular Weight
- 197.381
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Anesthetic (Inhalation)
- Anesthetics
- Anesthetics, General
- Anesthetics, Inhalation
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Code
- TWA (50 ppm); Not classifiable as a human carcinogen
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Names and Synonyms
Name of Substance
- 2-Bromo-2-chloro-1,1,1-trifluoroethane
- Halothane
- Halothane [USP:INN:BAN:JAN]
MeSH Heading
- Halothane
Synonyms
- (+-)-2-Bromo-2-chloro-1,1,1-trifluoroethane
- 1,1,1-Trifluoro-2-bromo-2-chloroethane
- 1,1,1-Trifluoro-2-chloro-2-bromoethane
- 1-Bromo-1-chloro-2,2,2-trifluoroethane
- 2,2,2-Trifluoro-1-chloro-1-bromoethane
- 2-Brom-2-chlor-1,1,1-trifluorethan
- 2-Bromo-2-chloro-1,1,1-trifluoroethane
- 4-01-00-00156 (Beilstein Handbook Reference)
- Alotano
- Alotano [DCIT]
- Anestan
- BRN 1736947
- Bromchlortrifluoraethanum
- Bromochlorotrifluoroethane
- CCRIS 6244
- Chalothane
- EINECS 205-796-5
- Ethane, 1-bromo-1-chloro-2,2,2-trifluoro-
- Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-, (+-)-
- Fluktan
- Fluorotane
- Fluothane
- Freon 123B1
- Ftorotan
- Ftorotan [Russian]
- Ftuorotan
- Halan
- Halotan
- Halotano
- Halotano [INN-Spanish]
- Halothan
- Halothane
- Halothanum
- Halothanum [INN-Latin]
- Halsan
- HSDB 6753
- Narcotan
- Narcotane
- Narcotann NE-spofa
- Narcotann NE-spofa [Russian]
- Narkotan
- NSC 143490
- Phthorothanum
- Rhodialothan
- UNII-UQT9G45D1P
Systematic Names
- Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-
- Halothane
Superlist Names
- Halothane
- Halothane [Anaesthetics, volatile]
Registry Numbers
CAS Registry Number
- 151-67-7
FDA UNII
- UQT9G45D1P
System Generated Number
- 0000151677
Structure Descriptors
InChI
InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1HInChIKey
BCQZXOMGPXTTIC-UHFFFAOYSA-NSmiles
FC(F)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 6gm/kg (6000mg/kg) | BEHAVIORAL: ANTIPSYCHOTIC BEHAVIORAL: EXCITEMENT | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 36, 1980. |
human | LCLo | inhalation | 7000ppm/3H (7000ppm) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" GASTROINTESTINAL: NAUSEA OR VOMITING | Anesthesiology. Vol. 24, Pg. 29, 1963. |
man | LDLo | intravenous | 129mg/kg (129mg/kg) | CARDIAC: CHANGE IN RATE BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Lancet. Vol. 1, Pg. 340, 1982. |
mouse | LC50 | inhalation | 98gm/m3/2H (98000mg/m3) | BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 111, Pg. 10, 1975. |
rat | LC50 | inhalation | 29000ppm (29000ppm) | Farmakologiya i Toksikologiya Vol. 25, Pg. 143, 1962. | |
rat | LD50 | oral | 5680mg/kg (5680mg/kg) | BEHAVIORAL: ANTIPSYCHOTIC BEHAVIORAL: EXCITEMENT | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 36, 1980. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -1.18E+02 | deg C | EXP | |
Boiling Point | 50.2 | deg C | EXP | |
log P (octanol-water) | 2.3 | (none) | EXP | |
Water Solubility | 4070 | mg/L | 25 | EXP |
Vapor Pressure | 302 | mm Hg | 25 | EXP |
Henry's Law Constant | 0.0203 | atm-m3/mole | 25 | EXP |
Atmospheric OH Rate Constant | 4.50E-14 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.