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Substance Name: Halothane [USP:INN:BAN:JAN]
RN: 151-67-7
UNII: UQT9G45D1P
InChIKey: BCQZXOMGPXTTIC-UHFFFAOYSA-N

Note

  • A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)

Molecular Formula

  • C2-H-Br-Cl-F3

Molecular Weight

  • 197.381
 

Classification Codes

Classification Codes

  • Anesthetic (Inhalation)
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, Inhalation
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Code

  • TWA (50 ppm); Not classifiable as a human carcinogen

Names and Synonyms

Name of Substance

  • 2-Bromo-2-chloro-1,1,1-trifluoroethane
  • Halothane
  • Halothane [USP:INN:BAN:JAN]

MeSH Heading

  • Halothane

Synonyms

  • (+-)-2-Bromo-2-chloro-1,1,1-trifluoroethane
  • 1,1,1-Trifluoro-2-bromo-2-chloroethane
  • 1,1,1-Trifluoro-2-chloro-2-bromoethane
  • 1-Bromo-1-chloro-2,2,2-trifluoroethane
  • 2,2,2-Trifluoro-1-chloro-1-bromoethane
  • 2-Brom-2-chlor-1,1,1-trifluorethan
  • 2-Bromo-2-chloro-1,1,1-trifluoroethane
  • 4-01-00-00156 (Beilstein Handbook Reference)
  • Alotano
  • Alotano [DCIT]
  • Anestan
  • BRN 1736947
  • Bromchlortrifluoraethanum
  • Bromochlorotrifluoroethane
  • CCRIS 6244
  • Chalothane
  • EINECS 205-796-5
  • Ethane, 1-bromo-1-chloro-2,2,2-trifluoro-
  • Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-, (+-)-
  • Fluktan
  • Fluorotane
  • Fluothane
  • Freon 123B1
  • Ftorotan
  • Ftorotan [Russian]
  • Ftuorotan
  • Halan
  • Halotan
  • Halotano
  • Halotano [INN-Spanish]
  • Halothan
  • Halothane
  • Halothanum
  • Halothanum [INN-Latin]
  • Halsan
  • HSDB 6753
  • Narcotan
  • Narcotane
  • Narcotann NE-spofa
  • Narcotann NE-spofa [Russian]
  • Narkotan
  • NSC 143490
  • Phthorothanum
  • Rhodialothan
  • UNII-UQT9G45D1P

Systematic Names

  • Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-
  • Halothane

Superlist Names

  • Halothane
  • Halothane [Anaesthetics, volatile]

Registry Numbers

CAS Registry Number

  • 151-67-7

FDA UNII

  • UQT9G45D1P

System Generated Number

  • 0000151677

Structure Descriptors

InChI

1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H

InChIKey

BCQZXOMGPXTTIC-UHFFFAOYSA-N

Smiles

C([C@@H](Cl)Br)(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 6gm/kg (6000mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 36, 1980.
human LCLo inhalation 7000ppm/3H (7000ppm) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

GASTROINTESTINAL: NAUSEA OR VOMITING
Anesthesiology. Vol. 24, Pg. 29, 1963.
man LDLo intravenous 129mg/kg (129mg/kg) CARDIAC: CHANGE IN RATE

BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Lancet. Vol. 1, Pg. 340, 1982.
mouse LC50 inhalation 98gm/m3/2H (98000mg/m3) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

LIVER: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 111, Pg. 10, 1975.
rat LC50 inhalation 29000ppm (29000ppm)   Farmakologiya i Toksikologiya Vol. 25, Pg. 143, 1962.
rat LD50 oral 5680mg/kg (5680mg/kg) BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 36, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.18E+02 deg C   EXP
Boiling Point 50.2 deg C   EXP
log P (octanol-water) 2.3 (none)   EXP
Water Solubility 4070 mg/L 25 EXP
Vapor Pressure 302 mm Hg 25 EXP
Henry's Law Constant 0.0203 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 4.50E-14 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.