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Substance Name: Betamethasone sodium phosphate [USP:JAN]
RN: 151-73-5
UNII: 7BK02SCL3W
InChIKey: PLCQGRYPOISRTQ-LWCNAHDDSA-L

Note

  • Phosphate ester of betamethasone.

Molecular Formula

  • C22-H30-F-O8-P.2Na

Molecular Weight

  • 516.4072
 

Classification Codes

  • Adrenal Cortex Hormones
  • Glucocorticoid
  • Glucocorticoids
  • Hormone
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Bentelan
  • Betamethasone sodium phosphate [USP:JAN]

Synonyms

  • 9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(disodium phosphate)
  • BDP
  • Bentelan
  • beta-Methasone disodium phosphate
  • beta-Methasone phosphate
  • beta-Methasone sodium phosphate
  • beta-Methasone, disodium phosphate
  • Betamethasone 21-disodium phosphate
  • Betamethasone disodium phosphate
  • Betamethasone sodium phosphate
  • Betamethazone disodium phosphate
  • Betasone (Veterinary)
  • Betavet Soluspan (Veterinary)
  • Betnesol
  • Celestone
  • Celestone Phosphate
  • Celestone Phosphate Injection
  • Disodium betamethasone 21-phosphate
  • EINECS 205-797-0
  • Linolosal
  • Linosal
  • NSC 90616
  • UNII-7BK02SCL3W

Systematic Names

  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16beta)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-, 21-(dihydrogen phosphate), disodium salt
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-, 21-(dihydrogen phosphate), disodium salt (8CI)

Mixture Name

  • Celestone soluspan

Registry Numbers

CAS Registry Number

  • 151-73-5

FDA UNII

  • 7BK02SCL3W

Related Registry Number

  • 360-63-4 (parent)

System Generated Number

  • 0000151735

Molecular Formulas

Molecular Formula

  • C22-H30-F-O8-P.2Na

Molecular Formula Fragments

  • C22-H30-F-O8-P
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

InChIKey

PLCQGRYPOISRTQ-LWCNAHDDSA-L

Smiles

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1166mg/kg (1166mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
mouse LD50 intravenous 1304mg/kg (1304mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
mouse LD50 oral 1607mg/kg (1607mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
mouse LD50 subcutaneous 1363mg/kg (1363mg/kg)   Shikoku Igaku Zasshi. Shikoku Medical Journal. Vol. 29, Pg. 153, 1973.
rat LD50 intramuscular 1291mg/kg (1291mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
rat LD50 intraperitoneal 1179mg/kg (1179mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
rat LD50 intravenous 1276mg/kg (1276mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rat LD50 oral 1877mg/kg (1877mg/kg)   Drugs in Japan Vol. -, Pg. 1075, 1990.
rat LD50 subcutaneous 1265mg/kg (1265mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 52, Pg. 105, 1996.