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Substance Name: Rifamycin, monosodium salt
RN: 15105-92-7
InChIKey: YVOFSHPIJOYKSH-NLYBMVFSSA-M

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C37-H47-N-O12.Na

Molecular Weight

  • 719.7554
 
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Names and Synonyms

Results Name

  • Rifamycin, monosodium salt

Synonyms

  • Monosodium rifamycin SV
  • NSC 133100
  • Rifamycin
  • Rifamycin sodium salt
  • Rifamycin SV
  • Rifocin
  • Sodium rifomycin SV

Systematic Names

  • 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, monosodium salt (8CI)
  • 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-, 21-acetate, sodium
  • Rifamycin, monosodium salt (9CI)

Registry Numbers

CAS Registry Number

  • 15105-92-7

Related Registry Number

  • 6998-60-3 (Parent)

System Generated Number

  • 0015105927

Molecular Formulas

Molecular Formula

  • C37-H47-N-O12.Na

Molecular Formula Fragments

  • C37-H47-N-O12
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C37H47NO12.Na/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);/q;+1/p-1/b11-10+,14-13+,17-12-;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;/m0./s1

InChIKey

YVOFSHPIJOYKSH-NLYBMVFSSA-M

Smiles

Cc1c(c2c3c(cc(c2O)NC(=O)/C(=C\C=C\[C@@H]([C@@H]([C@H]([C@H]([C@H]([C@@H]([C@@H]([C@H](/C=C/O[C@@]4(C(=O)c3c1O4)C)OC)C)OC(=O)C)C)O)C)O)C)/C)[O-])O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 oral 1952mg/kg (1952mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Veterinarno-Meditsinski Nauki. Veterinary Science. Vol. 24(10), Pg. 21, 1987.
dog LD50 intravenous 350mg/kg (350mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Farmaco, Edizione Scientifica. Vol. 16, Pg. 235, 1961.
guinea pig LD50 intraperitoneal 317mg/kg (317mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 325, 1970.
mouse LD50 intraperitoneal 625mg/kg (625mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Farmaco, Edizione Scientifica. Vol. 16, Pg. 235, 1961.
mouse LD50 intravenous 550mg/kg (550mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Farmaco, Edizione Scientifica. Vol. 16, Pg. 235, 1961.
mouse LD50 oral 2120mg/kg (2120mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Farmaco, Edizione Scientifica. Vol. 16, Pg. 235, 1961.
mouse LD50 subcutaneous 1080mg/kg (1080mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Farmaco, Edizione Scientifica. Vol. 16, Pg. 235, 1961.
rat LD50 intraperitoneal 480mg/kg (480mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Farmaco, Edizione Scientifica. Vol. 16, Pg. 235, 1961.
rat LD50 intravenous 595mg/kg (595mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 324, 1970.
rat LD50 oral 2680mg/kg (2680mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Farmaco, Edizione Scientifica. Vol. 16, Pg. 235, 1961.
rat LD50 subcutaneous 1120mg/kg (1120mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Farmaco, Edizione Scientifica. Vol. 16, Pg. 235, 1961.