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Substance Name: Andecaliximab [USAN]
RN: 1518996-49-0
UNII: 571045EIM4


  • Anti-matrix metalloproteinase-9 monoclonal antibody for treatment of ulcerative colitis.

    NCI: anti-MMP-9 monoclonal antibody GS-5745 A humanized monoclonal antibody against matrix metalloproteinase 9 (MMP-9), with potential antineoplastic activity. Upon administration, anti-MMP-9 monoclonal antibody GS-5745 binds to MMP-9 and inhibits its enzymatic activity. This results in an inhibition of extracellular matrix protein degradation and, potentially, the inhibition of angiogenesis, tumor growth, invasion, and metastasis. MMP-9, a protein belonging to the MMP family, plays a key role in the degradation of collagens and proteoglycans; increased activity of MMP-9 has been associated with increased invasion and metastasis of cancer. (NCI Thesaurus)

Molecular Formula

  • C6396-H9868-N1680-O2010-S46 (non-glycosylated)

Classification Code

  • Treatment of Cancer and Inflammatory Diseases
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Links to Resources

Names and Synonyms

Name of Substance

  • Andecaliximab [USAN]
  • GS-5745


  • Andecaliximab
  • GS 5745
  • GS-5745
  • GS5745
  • UNII-571045EIM4

Registry Numbers

CAS Registry Number

  • 1518996-49-0


  • 571045EIM4

System Generated Number

  • 1518996490