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Substance Name: Dydrogesterone [USAN:USP:INN:BAN:JAN]
RN: 152-62-5
UNII: 90I02KLE8K
InChIKey: JGMOKGBVKVMRFX-HQZYFCCVSA-N

Note

  • A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit OVULATION.

Molecular Formula

  • C21-H28-O2

Molecular Weight

  • 312.4502
 

Classification Codes

  • Hormone
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Progestin
  • Progestins
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Dydrogesterone
  • Dydrogesterone [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Dydrogesterone

Synonyms

  • (9-beta,10-alpha)-Pregna-4,6-diene-3,20-dione
  • 10alpha-Isopregnenone
  • 6-Dehydro-9beta,10alpha-progesterone
  • 6-Dehydro-retro-progesterone
  • 9-beta,10alpha-Pregna-4,6-diene-3,20-dione
  • 9beta,10alpha-Pregna-4,6-diene-3,20-dione
  • CCRIS 9069
  • delta(6)-Retroprogesterone
  • delta(sup 6)-Retroprogesterone
  • Didrogesterone
  • Didrogesterone [DCIT]
  • Diphaston
  • Dufaston
  • Duphaston
  • Duvaron
  • Dydrogesterona
  • Dydrogesterona [INN-Spanish]
  • Dydrogesterone
  • Dydrogesteronum
  • Dydrogesteronum [INN-Latin]
  • EINECS 205-806-8
  • Gestatron
  • Gynorest
  • HSDB 3321
  • Hydrogesterone
  • Hydrogestrone
  • Isopregnenone
  • NSC 92336
  • Pregna-4,6-diene-3,20-dione, (9beta,10alpha)-
  • Prodel
  • Retro-6-dehydroprogesterone
  • Retrone
  • Retroprogesterone, 6-dehydro-
  • Terolut
  • UNII-90I02KLE8K

Systematic Names

  • 9-beta,10-alpha-Pregna-4,6-diene-3,20-dione
  • 9beta,10alpha-Pregna-4,6-diene-3,20-dione (8CI)
  • Dydrogesterone
  • Pregna-4,6-diene-3,20-dione, (9-beta,10-alpha)- (9CI)
  • Pregna-4,6-diene-3,20-dione, (9beta,10alpha)-

Registry Numbers

CAS Registry Number

  • 152-62-5

FDA UNII

  • 90I02KLE8K

System Generated Number

  • 0000152625

Structure Descriptors

InChI

1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20+,21+/m0/s1

InChIKey

JGMOKGBVKVMRFX-HQZYFCCVSA-N

Smiles

CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@@H]3[C@H]2C=CC4=CC(=O)CC[C@@]34C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 7200mg/kg (7200mg/kg)   Drugs in Japan Vol. 6, Pg. 324, 1982.
rat LD50 oral > 4600mg/kg (4600mg/kg)   Drugs in Japan Vol. 6, Pg. 324, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 169.5 deg C   EXP
log P (octanol-water) 3.450 (none)   EST
Atmospheric OH Rate Constant 1.94E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.