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Substance Name: Fluocortolone [USAN:INN:BAN]
RN: 152-97-6
UNII: 65VXC1MH0J
InChIKey: GAKMQHDJQHZUTJ-ULHLPKEOSA-N

Note

  • A glucocorticoid with anti-inflammatory activity used topically for various skin disorders.

Molecular Formula

  • C22-H29-F-O4

Molecular Weight

  • 376.4651
 

Classification Codes

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Glucocorticoid
  • Glucocorticoids
  • Hormone
  • Hormones
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Fluocortolone
  • Fluocortolone [USAN:INN:BAN]

MeSH Heading

  • Fluocortolone

Synonyms

  • 6-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
  • 6-alpha-Fluoro-16-alpha-methyl-1-dehydrocorticosterone
  • 6-alpha-Fluoro-16-alpha-methyl-delta(sup 1,4)-pregnadiene-11-beta-diol-3,20-dione
  • 6-alpha-Fluoro-16-alpha-methylpregna-1,4-diene-11-beta,21-diol-3,20-dione
  • 6alpha-Fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
  • BRN 3122594
  • EC 205-811-5
  • EINECS 205-811-5
  • Fluocortolon
  • Fluocortolona
  • Fluocortolona [INN-Spanish]
  • Fluocortolone
  • Fluocortolonum
  • Fluocortolonum [INN-Latin]
  • Fluorcortolone
  • Fluorocortolone
  • SH 742
  • Ultralan oral
  • UNII-65VXC1MH0J

Systematic Names

  • Fluocortolone
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-

Registry Numbers

CAS Registry Number

  • 152-97-6

FDA UNII

  • 65VXC1MH0J

System Generated Number

  • 0000152976

Structure Descriptors

InChI

1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1

InChIKey

GAKMQHDJQHZUTJ-ULHLPKEOSA-N

Smiles

[C@H]12[C@H]3[C@@]([C@H]([C@@H](C3)C)C(=O)CO)(C[C@@H]([C@@H]1[C@@]1(C(=CC(=O)C=C1)[C@H](C2)F)C)O)C

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 188 deg C   EXP
log P (octanol-water) 2.060 (none)   EST
Water Solubility 290 mg/L 37 EXP
Atmospheric OH Rate Constant 6.76E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.