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Substance Name: Nebivolol Hydrochloride [USAN]
RN: 152520-56-4
UNII: JGS34J7L9I
InChIKey: JWEXHQAEWHKGCW-VCVZPGOSSA-N

Notes

  • Highly selective b1 antagonist with non-adrenergic vasodilating properties due to the release of nitric oxide from vascular endothelium, studied in the treatment of hypertension, congestive heart failure and other cardiovascular.
  • Selective b1-blocker with additional vasodilator effects which are mediated by the endothelial L-arginine/nitric oxide system.

Molecular Formula

  • C22-H25-F2-N-O4.Cl-H

Molecular Weight

  • 441.8994
 

Names and Synonyms

Name of Substance

  • Nebivolol Hydrochloride [USAN]

Synonyms

  • Bystolic
  • Nebilet
  • Nebivolol Hydrochloride
  • R 67555
  • R-67555
  • R067555
  • Silostar
  • UNII-JGS34J7L9I

Systematic Names

  • (1RS,1'RS)-1,1'-((2RS,2'SR)-bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl))-2,2'-iminodiethanol hydrochloride
  • 2H-1-benzopyran-2-methanol, alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro-, hydrochloride, (alphaR,alpha'R,2R,2'S)-rel-

Registry Numbers

CAS Registry Number

  • 152520-56-4

FDA UNII

  • JGS34J7L9I

System Generated Number

  • 0152520564

Structure Descriptors

InChI

1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/m1./s1

InChIKey

JWEXHQAEWHKGCW-VCVZPGOSSA-N

Smiles

Cl.O[C@H](CNC[C@@H](O)[C@H]1CCc2cc(F)ccc2O1)[C@@H]3CCc4cc(F)ccc4O3