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Substance Name: Oxypertine [USAN:INN:BAN:JAN]
RN: 153-87-7
UNII: 5JGL4G25R7
InChIKey: XCWPUUGSGHNIDZ-UHFFFAOYSA-N

Note

  • Antipsychotic agent also used in severe depression; it has potentially dangerous side effects.

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent

Molecular Formula

  • C23-H29-N3-O2

Molecular Weight

  • 379.5011
 
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Names and Synonyms

Name of Substance

  • Oxypertine
  • Oxypertine [USAN:INN:BAN:JAN]

Synonyms

  • 1H-Indole, 5,6-dimethoxy-2-methyl-3-(2-(4-phenyl-1-piperazinyl)ethyl)-
  • 5,6-Dimethoxy-2-methyl-3-(2-(4-phenyl-1-piperazinyl)ethyl)indole
  • 5-23-03-00112 (Beilstein Handbook Reference)
  • BRN 0899339
  • DO 180
  • EINECS 205-818-3
  • Equipertine
  • Forit
  • Integrin
  • Opertil
  • Oxipertina
  • Oxipertina [INN-Spanish]
  • Oxipertinum
  • Oxypertine
  • Oxypertinum
  • Oxypertinum [INN-Latin]
  • UNII-5JGL4G25R7
  • Win 18,501-2
  • WIN 18501-2

Systematic Names

  • 1H-Indole, 5,6-dimethoxy-2-methyl-3-(2-(4-phenyl-1-piperazinyl)ethyl)-
  • Oxypertine

Registry Numbers

CAS Registry Number

  • 153-87-7

FDA UNII

  • 5JGL4G25R7

System Generated Number

  • 0000153877

Structure Descriptors

InChI

1S/C23H29N3O2/c1-17-19(20-15-22(27-2)23(28-3)16-21(20)24-17)9-10-25-11-13-26(14-12-25)18-7-5-4-6-8-18/h4-8,15-16,24H,9-14H2,1-3H3

InChIKey

XCWPUUGSGHNIDZ-UHFFFAOYSA-N

Smiles

Cc1c(c2cc(c(cc2[nH]1)OC)OC)CCN3CCN(CC3)c4ccccc4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 154mg/kg (154mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: REGIDITY

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Pharmacology and Chemotherapy. Vol. 26, Pg. 186, 1966.
mouse LD50 oral 2300mg/kg (2300mg/kg)   Drugs in Japan Vol. 6, Pg. 154, 1982.
mouse LD50 subcutaneous 2288mg/kg (2288mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 12(10), Pg. 1442, 1970.
rat LD50 intraperitoneal 938mg/kg (938mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 12(10), Pg. 1442, 1970.
rat LD50 oral 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 154, 1982.
rat LD50 subcutaneous 1944mg/kg (1944mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 12(10), Pg. 1442, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.850 (none)   EST
Atmospheric OH Rate Constant 4.69E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.