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Substance Name: Bezitramide [INN:BAN:DCF]
RN: 15301-48-1
UNII: 3KXW0Y310I
InChIKey: FLKWNFFCSSJANB-UHFFFAOYSA-N

Molecular Formula

  • C31-H32-N4-O2

Molecular Weight

  • 492.6198
 

Classification Codes

Classification Codes

  • Analgesics
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule II
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Names and Synonyms

Name of Substance

  • Bezitramide
  • Bezitramide [INN:BAN:DCF]

Synonyms

  • 1-(1-(3-Cyano-3,3-diphenylpropyl)-4-piperidyl)-3-propionyl-2-benzimidazolinone
  • 1-(3-Cyano-3,3-diphenylpropyl)-4-(2-oxo-3-propionyl-1-benzimidazolinyl)piperidine
  • 5-24-02-00382 (Beilstein Handbook Reference)
  • Benzitramide
  • Bezitramida
  • Bezitramida [INN-Spanish]
  • Bezitramide
  • Bezitramidum
  • Bezitramidum [INN-Latin]
  • BRN 0905485
  • Burgodin
  • EINECS 239-335-4
  • R 4845
  • R-4845
  • UNII-3KXW0Y310I

Systematic Names

  • 1-(1-(3-Cyano-3,3-diphenylpropyl)-4-piperidyl)-3-propionyl-2-benzimidazolinone
  • 1-(3-Cyano-3,3-diphenylpropyl)-4-(2-oxo-3-propionyl-1-benzimidazolinyl)piperidine
  • 2-Benzimidazolinone, 1-(1-(3-cyano-3,3-diphenylpropyl)-4-piperidyl)-3-propionyl-
  • Bezitramide

Superlist Names

  • Bezitramide
  • DEA No. 9800

Registry Numbers

CAS Registry Number

  • 15301-48-1

FDA UNII

  • 3KXW0Y310I

System Generated Number

  • 0015301481

Structure Descriptors

InChI

1S/C31H32N4O2/c1-2-29(36)35-28-16-10-9-15-27(28)34(30(35)37)26-17-20-33(21-18-26)22-19-31(23-32,24-11-5-3-6-12-24)25-13-7-4-8-14-25/h3-16,26H,2,17-22H2,1H3

InChIKey

FLKWNFFCSSJANB-UHFFFAOYSA-N

Smiles

CCC(=O)N1C(=O)N(C2CCN(CCC(C#N)(c3ccccc3)c4ccccc4)CC2)c5ccccc15

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 80mg/kg (80mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 862, 1971.
guinea pig LD50 oral 60400ug/kg (60.4mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 862, 1971.
mouse LD50 oral 2101mg/kg (2101mg/kg) BEHAVIORAL: EXCITEMENT

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 862, 1971.
rat LD50 oral 141mg/kg (141mg/kg) BEHAVIORAL: REGIDITY

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 862, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 145-149 deg C   EXP
log P (octanol-water) 4.8 (none)   EXP
Water Solubility 0.092 mg/L 25 EST
Vapor Pressure 1.29E-14 mm Hg 25 EST
Henry's Law Constant 2.22E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.34E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.