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Substance Name: Diclofenac sodium [USAN:USP:JAN]
RN: 15307-79-6
UNII: QTG126297Q
InChIKey: KPHWPUGNDIVLNH-UHFFFAOYSA-M

Note

  • A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

Molecular Formulas

  • C14-H10-Cl2-N-Na-O2
  • C14-H10-Cl2-N-O2.Na
  • C14-H11-Cl2-N-O2.Na

Molecular Weight

  • 318.134
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Cyclooxygenase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Human Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Diclofenac sodium [USAN:USP:JAN]

Synonyms

  • (o-(2,6-Dichloroanilino)phenyl)acetic acid monosodium salt
  • (o-(2,6-Dichloroanilino)phenyl)acetic acid sodium salt
  • 2-((2,6-Dichlorophenyl)amino)benzeneacetic acid monosodium salt
  • Abitren
  • Allvoran
  • Anthraxiton
  • Assaren
  • Ba 47210
  • Batafil
  • Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-, monosodium salt
  • Berifen
  • Blesin
  • CCRIS 1909
  • Delimon
  • Delphimix
  • DIC075V
  • Dichronic
  • Diclofenac sodium
  • Diclofenac sodium injection
  • Diclofenac sodium topical gel
  • Diclophenac sodium
  • Dyloject
  • EC 239-346-4
  • EINECS 239-346-4
  • GP 45840
  • Kriplex
  • Neriodin
  • Olfen
  • Orthophen
  • Ortofen
  • Pennsaid
  • Prophenatin
  • Sodium (o-((2,6-dichlorophenyl)amino)phenyl)acetate
  • Sodium (o-(2,6-dichloroanilino)phenyl) acetate
  • Sodium (o-(2,6-dichloroanilino)phenyl)acetate
  • Sodium diclofenac
  • Solaraze
  • TDS 943
  • Tsudohmin
  • UNII-QTG126297Q
  • Urigon
  • Valetan
  • Voltaren
  • Voltaren Gel
  • Voltaren ophthalmic
  • Voltaren-XR
  • Voltarene
  • Voltarol
  • Vonafec
  • Vurdon

Systematic Names

  • Acetic acid, o-(2,6-dichloroanilino)phenyl-, monosodium salt
  • Benzeneacetic acid, 2-((2,6-dichlorophenyl)amino)-, monosodium salt
  • Feloran
  • Sodium (2-((2,6-dichlorophenyl)amino)phenyl)acetate

Mixture Name

  • Arthrotec

Registry Numbers

CAS Registry Number

  • 15307-79-6

FDA UNII

  • QTG126297Q

Other Registry Number

  • 1147187-62-9

System Generated Number

  • 0015307796

Molecular Formulas

Molecular Formulas

  • C14-H10-Cl2-N-Na-O2
  • C14-H10-Cl2-N-O2.Na
  • C14-H11-Cl2-N-O2.Na

Molecular Formula Fragments

  • C14-H10-Cl2-N-O2
  • C14-H11-Cl2-N-O2
  • COMPONENT
  • Na

Structure Descriptors

InChI

InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1

InChIKey

KPHWPUGNDIVLNH-UHFFFAOYSA-M

Smiles

[Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 42mg/kg (42mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
dog LD50 oral 59mg/kg (59mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
mouse LD50 intraperitoneal 74mg/kg (74mg/kg)   Pharmaceutical Chemistry Journal Vol. 27, Pg. 343, 1993.
mouse LD50 intravenous 116mg/kg (116mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse LD50 oral 95mg/kg (95mg/kg)   Pharmaceutical Chemistry Journal Vol. 23, Pg. 579, 1989.
mouse LD50 subcutaneous 390mg/kg (390mg/kg)   Drugs in Japan Vol. 6, Pg. 311, 1982.
mouse LD50 unreported 380mg/kg (380mg/kg)   Pharmaceutical Chemistry Journal Vol. 21, Pg. 275, 1987.
rabbit LD50 intravenous > 100mg/kg (100mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
rabbit LD50 oral 157mg/kg (157mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 1521, 1972.
rat LD50 intraperitoneal 25mg/kg (25mg/kg)   Drugs in Japan Vol. 6, Pg. 311, 1982.
rat LD50 intravenous 117mg/kg (117mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 oral 53mg/kg (53mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 28, Pg. 99, 1981.
rat LD50 rectal 85400ug/kg (85.4mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 2259, 1986.
rat LD50 subcutaneous 83mg/kg (83mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
women TDLo intramuscular 9mg/kg/1W-I (9mg/kg) BLOOD: NORMOCYTIC ANEMIA

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
American Journal of Hematology. Vol. 58, Pg. 142, 1998.
women TDLo intramuscular 15mg/kg/5D-I (15mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: OTHER CHANGES
Lancet. Vol. 340, Pg. 126, 1992.
women TDLo oral 30mg/kg/10D-I (30mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Postgraduate Medical Journal. Vol. 69, Pg. 486, 1993.
women TDLo oral 112mg/kg/8W-I (112mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Archives of Internal Medicine. Vol. 152, Pg. 625, 1992.
women TDLo oral 180mg/kg/13W- (180mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: ANOREXIA (HUMAN

KIDNEY, URETER, AND BLADDER: PROTEINURIS
British Medical Journal. Vol. 295, Pg. 182, 1987.
women TDLo oral 183mg/kg/26W- (183mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
British Journal of Clinical Practice. Vol. 43, Pg. 125, 1989.
women TDLo oral 270mg/kg/90D- (270mg/kg) BLOOD: CHANGES IN ERYTHROCYTE (RBC) COUNT

GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE
Archives of Internal Medicine. Vol. 152, Pg. 625, 1992.
women TDLo oral 300mg/kg/17W- (300mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED Clinical Rheumatology. Vol. 11, Pg. 120, 1992.
women TDLo oral 2190mg/kg/2Y- (2190mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" American Journal of Gastroenterology. Vol. 90, Pg. 1871, 1995.
women TDLo unreported 364mg/kg/26W- (364mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

KIDNEY, URETER, AND BLADDER: PROTEINURIS
Wiener Klinische Wochenschrift. Vol. 111, Pg. 523, 1999.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 283-285 deg C   EXP
log P (octanol-water) 0.7 (none)   EXP
Water Solubility 2430 mg/L 25 EST
Vapor Pressure 4.75E-14 mm Hg 25 EST
Atmospheric OH Rate Constant 1.64E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.