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Substance Name: Phosphine oxide, tris(2,2-dimethyl-1-aziridinyl)-
RN: 15312-14-8
InChIKey: MPSCILDWLMBJKC-UHFFFAOYSA-N

Note

  • An alkylating agent, , was chosen for clinical trial because of its superior performance in animal tumor systems.

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C12-H24-N3-O-P

Molecular Weight

  • 257.316
 
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Names and Synonyms

Synonyms

  • AI3-50423
  • NSC 118436
  • SK6231
  • TEPA-132
  • Tris(2,2-dimethyl-1-aziridinyl)phosphine oxide
  • Tris(2,2-dimethylaziridinyl)phosphine oxide

Systematic Names

  • Aziridine, 1,1',1''-phosphinylidynetris(2,2-dimethyl- (9CI)
  • Aziridine, 1,1',l''-phosphinylidynetris(2,2-dimethyl-
  • Phosphine oxide, tris(2,2-dimethyl-1-aziridinyl)-

Registry Numbers

CAS Registry Number

  • 15312-14-8

System Generated Number

  • 0015312148

Structure Descriptors

InChI

1S/C12H24N3OP/c1-10(2)7-13(10)17(16,14-8-11(14,3)4)15-9-12(15,5)6/h7-9H2,1-6H3

InChIKey

MPSCILDWLMBJKC-UHFFFAOYSA-N

Smiles

P([N@@]1C(C)(C)C1)([N@@]1C(C)(C)C1)([N@@]1C(C)(C)C1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intravenous 12mg/kg (12mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Cancer Chemotherapy Reports, Part 1. Vol. 56, Pg. 393, 1972.