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Substance Name: Cevimeline hydrochloride [USAN]
RN: 153504-70-2
UNII: P81Q6V85NP
InChIKey: ZSTLCHCDLIUXJE-ZGBAEQJLSA-N

Classification Codes

  • Alzheimer's Disease Treatment (Adjunct)
  • Drug / Therapeutic Agent

Molecular Formula

  • C10-H17-N-O-S.Cl-H.1/2H2-O

Molecular Weight

  • 489.5692
 

Names and Synonyms

Name of Substance

  • Cevimeline hydrochloride [USAN]

Synonyms

  • (+-)-cis-2-Methylspiro(1,3-oxathiolane-5,3'-quinuclidine) hydrochloride, hemihydrate
  • AF102B
  • Cevimeline HCl 1/2H2O
  • Cevimeline hydrochloride
  • Cevimeline hydrochloride hemihydrate
  • cis-2-Methylspiro(1,3-oxathiolane-5,3')quinuclidine hydrochloride hydrate (2:2:1)
  • Evoxac
  • FKS-508
  • SND-5008
  • SNI-2011
  • SNK-508
  • Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane), 2'-methyl-, hydrochloride, hydrate (2:1), cis-
  • UNII-P81Q6V85NP

Systematic Name

  • Spiro(1-azabicyclo(2.2.2)octane-3,5'-(1,3)oxathiolane), 2'-methyl-, hydrochloride, hydrate (2:1), cis-

Registry Numbers

CAS Registry Number

  • 153504-70-2

FDA UNII

  • P81Q6V85NP

System Generated Number

  • 0153504702

Molecular Formulas

Molecular Formula

  • C10-H17-N-O-S.Cl-H.1/2H2-O

Molecular Formula Fragments

  • C10-H17-N-O-S
  • Cl-H
  • COMPONENT
  • H2-O

Structure Descriptors

InChI

1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m00.../s1

InChIKey

ZSTLCHCDLIUXJE-ZGBAEQJLSA-N

Smiles

O.Cl.Cl.C[C@H]1O[C@]2(CS1)CN3CCC2CC3.C[C@H]4O[C@]5(CS4)CN6CCC5CC6

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 40800ug/kg (40.8mg/kg)   United States Patent Document. Vol. #5340821,
mouse LD50 oral 139mg/kg (139mg/kg)   United States Patent Document. Vol. #5340821,
mouse LD50 subcutaneous 65mg/kg (65mg/kg)   United States Patent Document. Vol. #5340821,