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Substance Name: Buzepide metiodide [INN:DCF]
RN: 15351-05-0
UNII: 5A9SS67K16
InChIKey: HMFBCJNMIYZRKQ-UHFFFAOYSA-N

Note

  • Component of vesadol.

Classification Code

  • Reproductive Effect

Molecular Formulas

  • C23-H31-I-N2-O
  • C23-H31-N2-O.I

Molecular Weight

  • 478.411
 
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Names and Synonyms

Name of Substance

  • Buzepide metiodide
  • Buzepide metiodide [INN:DCF]

Synonyms

  • 2,2-Diphenyl-4-N-hexamethyleniminobutyramide methiodide
  • Buzepide methiodide
  • Buzepide metiodide
  • Buzepidi metiodidum
  • Buzepidi metiodidum [INN-Latin]
  • Difexamide methiodide
  • Diphexamide methiodide
  • EINECS 239-383-6
  • F.I. 6146
  • FI 6146
  • Metiodure de buzepide
  • Metiodure de buzepide [INN-French]
  • Metioduro de buzepida
  • Metioduro de buzepida [INN-Spanish]
  • R 661
  • Spactin
  • UNII-5A9SS67K16

Systematic Names

  • 1-(3-Carbamoyl-3,3-diphenylpropyl)perhydro-1-methylazepinium iodide
  • 1-(4-Amino-4-oxo-3,3-diphenylbutyl)hexahydro-1-methyl-1H-azepinium iodide
  • 1H-Azepinium, hexahydro-1-(3-carbamoyl-3,3-diphenylpropyl)-1-methyl-, iodide
  • Buzepide metiodide

Registry Numbers

CAS Registry Number

  • 15351-05-0

FDA UNII

  • 5A9SS67K16

System Generated Number

  • 0015351050

Molecular Formulas

Molecular Formulas

  • C23-H31-I-N2-O
  • C23-H31-N2-O.I

Molecular Formula Fragments

  • C23-H31-N2-O
  • COMPONENT
  • I

Structure Descriptors

InChI

1S/C23H30N2O.HI/c1-25(17-10-2-3-11-18-25)19-16-23(22(24)26,20-12-6-4-7-13-20)21-14-8-5-9-15-21;/h4-9,12-15H,2-3,10-11,16-19H2,1H3,(H-,24,26);1H

InChIKey

HMFBCJNMIYZRKQ-UHFFFAOYSA-N

Smiles

C(c1ccccc1)(c1ccccc1)(CC[N+]1(CCCCCC1)C)C(N)=O.[IH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 201mg/kg (201mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
mouse LD50 intraperitoneal 94mg/kg (94mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
mouse LD50 intravenous 14mg/kg (14mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
mouse LD50 oral 820mg/kg (820mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
mouse LD50 subcutaneous 229mg/kg (229mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat LD50 intramuscular 800mg/kg (800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat LD50 intraperitoneal 145mg/kg (145mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat LD50 intravenous 29300ug/kg (29.3mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat LD50 oral 2800mg/kg (2800mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.
rat LD50 subcutaneous 1210mg/kg (1210mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1850, 1970.