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Substance Name: Merphyrin
RN: 15375-94-7
UNII: 3937ZYJ7S1
InChIKey: MSWKATKSSLJVEX-HRSUBPLTSA-J

Classification Codes

  • Drug / Therapeutic Agent
  • Organometallic
  • Reproductive Effect

Molecular Formula

  • C34-H34-Hg-N4-O6.2Na

Molecular Weight

  • 841.235
 
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Names and Synonyms

Name of Substance

  • Merphyrin

Synonyms

  • Hematoporphyrin mercury (II)
  • Hematoporphyrin, mercury(II) deriv., disodium salt
  • Hematoporphyrinmercury disodium salt
  • Hg-Hematoporphyrin-NA
  • M. H.
  • Mercuri-hematoporphyrin disodium salt
  • Merphyllin
  • Merphyrin
  • NSC 66393
  • UNII-3937ZYJ7S1

Systematic Names

  • Mercurate(2-), (7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24)-, disodium, (SP-4-2)- (9CI)
  • Mercury, (dihydrogen 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18- porphinedipropionate(2-))-, disodium salt
  • Mercury, (dihydrogen 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionate(1-))-, disodium salt (8CI)

Registry Numbers

CAS Registry Number

  • 15375-94-7

FDA UNII

  • 3937ZYJ7S1

System Generated Number

  • 0015375947

Molecular Formulas

Molecular Formula

  • C34-H34-Hg-N4-O6.2Na

Molecular Formula Fragments

  • C34-H34-Hg-N4-O6
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C34H38N4O6.Hg.2Na/c1-15-21(7-9-31(41)42)27-14-28-22(8-10-32(43)44)16(2)24(36-28)12-29-34(20(6)40)18(4)26(38-29)13-30-33(19(5)39)17(3)25(37-30)11-23(15)35-27;;;/h11-14,19-20,39-40H,7-10H2,1-6H3,(H4,35,36,37,38,41,42,43,44);;;/q;+2;2*+1/p-4/b23-11-,24-12-,25-11-,26-13-,27-14-,28-14-,29-12-,30-13-;;;

InChIKey

MSWKATKSSLJVEX-HRSUBPLTSA-J

Smiles

[Na+].c1(c2cc3nc(cc4[n-]c(c(c4[C@@H](O)C)C)cc4nc(cc(c1C)[n-]2)C(C)=C4[C@@H](C)O)C(=C3CCC([O-])=O)C)CCC([O-])=O.[Hg+2].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intracrebral 380ug/kg (0.38mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 57, Pg. 219, 1961.
mouse LD50 intraperitoneal 23mg/kg (23mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 57, Pg. 219, 1961.
mouse LD50 intravenous 11500ug/kg (11.5mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 57, Pg. 219, 1961.
mouse LD50 subcutaneous 30mg/kg (30mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 57, Pg. 219, 1961.