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Substance Name: Niprofazone [INN]
RN: 15387-10-7
UNII: 0A995E1KA6
InChIKey: MZQAQBDIKUFBSF-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H25-N5-O2

Molecular Weight

  • 379.4615
 
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Names and Synonyms

Name of Substance

  • Niprofazone [INN]

Synonyms

  • 1-Phenyl-2,3-dimethyl-4(N-nicotinamidomethyl-N-isopropyl)amino-5-pyrazolone
  • 5-25-14-00124 (Beilstein Handbook Reference)
  • 5-Pyrazolone, 1-phenyl-2,3-dimethyl-4-(N-nicotinamidomethyl-N-isopropyl)amino-
  • BRN 0766712
  • N-(((2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)(1-methylethyl)amino)methyl)-3-pyridinecarboxamide
  • N-((Antipyrinylisopropylamino)methyl)nicotinamide
  • N-(N-(2,5-Dihydro-2,3-dimethyl-5-oxo-1-phenyl-4-pyrazolyl)-N-isopropylaminomethyl)nicotinamid
  • Nicotinamidomethylaminopyrazolone
  • Niprofazona
  • Niprofazona [INN-Spanish]
  • Niprofazone
  • Niprofazonum
  • Niprofazonum [INN-Latin]
  • RA 101
  • Ra 101 (pharmaceutical)
  • UNII-0A995E1KA6

Systematic Names

  • 3-Pyridinecarboxamide, N-(((2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)(1-methylethyl)amino)methyl)-
  • N-((Antipyrinylisopropylamino)methyl)nicotinamide
  • Nicotinamide, N-((antipyrinylisopropylamino)methyl)-

Registry Numbers

CAS Registry Number

  • 15387-10-7

FDA UNII

  • 0A995E1KA6

System Generated Number

  • 0015387107

Structure Descriptors

InChI

1S/C21H25N5O2/c1-15(2)25(14-23-20(27)17-9-8-12-22-13-17)19-16(3)24(4)26(21(19)28)18-10-6-5-7-11-18/h5-13,15H,14H2,1-4H3,(H,23,27)

InChIKey

MZQAQBDIKUFBSF-UHFFFAOYSA-N

Smiles

Cc1c(c(=O)n(n1C)c2ccccc2)N(CNC(=O)c3cccnc3)C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 intraperitoneal 853mg/kg (853mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1024, 1970.
mouse LD50 intraperitoneal 1060mg/kg (1060mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1024, 1970.
mouse LD50 oral 1460mg/kg (1460mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1024, 1970.
rat LD50 intraperitoneal 500mg/kg (500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1024, 1970.