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Substance Name: Tripelennamine hydrochloride [USP]
RN: 154-69-8
UNII: FWV8GJ56ZN
InChIKey: FSSICIQKZGUEAE-UHFFFAOYSA-N

Note

  • A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.

Molecular Formula

  • C16-H21-N3.Cl-H

Molecular Weight

  • 291.824
 

Classification Codes

  • Antihistaminic
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Tripelennamine hydrochloride [USP]

Synonyms

  • 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride
  • 2-(Benzyl(2-(dimethylamino)ethyl)amino)pyridine hydrochloride
  • 2-(Benzyl(2-(dimethylamino)ethyl)amino)pyridine monohydrochloride
  • Ahistamin
  • AntiAllergicum Medivet
  • CCRIS 1969
  • Dehistin
  • Dehistin monohydrochloride
  • EINECS 205-833-5
  • Ethylenediamine, N-benzyl-N',N'-dimethyl-N-(2-pyridyl)-, hydrochloride
  • N(sup 1)-alpha-Pyridyl-N(sup 1)-benzyl-N,N-dimethyl ethylenediamine monohydrochloride
  • N,N-Dimethyl-N'-(2-pyridyl)-N'-benzylethylenediamine hydrochloride
  • N-Benzyl-N',N'-dimethyl-N-2-pyridyl-ethylenediamine hydrochloride
  • N-Benzyl-N-alpha-pyridyl-N',N'-dimethyl-aethylendiamin-hydrochlorid
  • N-Benzyl-N-alpha-pyridyl-N',N'-dimethyl-aethylendiamin-hydrochlorid [German]
  • N-Benzyl-N-dimethylaminoethyl alpha-aminopyridine hydrochloride
  • NIH 10186
  • NSC 409943
  • PBZ
  • PBZ-SR
  • Piristin
  • Pyribenzamine hydrochloride
  • Pyribenzamine monohydrochloride
  • Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-, hydrochloride
  • Pyrinamine
  • Re-Covr Injectable (Veterinary)
  • ReCovr
  • Stanzamine
  • Tri-Tumine
  • Tripelennamine HCl
  • Tripelennamine hydrochloride
  • Tripelennamine monohydrochloride
  • UNII-FWV8GJ56ZN

Systematic Names

  • 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride
  • Pyribenzamine hydrochloride
  • Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-, monohydrochloride
  • Tripelennamine hydrochloride

Registry Numbers

CAS Registry Number

  • 154-69-8

FDA UNII

  • FWV8GJ56ZN

Related Registry Number

  • 91-81-6 (Parent)

System Generated Number

  • 0000154698

Molecular Formulas

Molecular Formula

  • C16-H21-N3.Cl-H

Molecular Formula Fragments

  • C16-H21-N3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H

InChIKey

FSSICIQKZGUEAE-UHFFFAOYSA-N

Smiles

N(c1ccccn1)(Cc1ccccc1)CCN(C)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 20mg/kg (20mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1916, 1969.
dog LDLo oral 23mg/kg (23mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: EXCITEMENT
Bulletin of the Johns Hopkins Hospital. Vol. 81, Pg. 55, 1947.
guinea pig LD50 oral 150mg/kg (150mg/kg)   Journal of Allergy. Vol. 27, Pg. 57, 1956.
guinea pig LD50 subcutaneous 30mg/kg (30mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
hamster LD50 intravenous 13mg/kg (13mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 371, 1949.
man LDLo unreported 15mg/kg (15mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse LD50 intraperitoneal 47mg/kg (47mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Clinical Toxicology. Vol. 16, Pg. 17, 1980.
mouse LD50 intravenous 9mg/kg (9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 249, 1948.
mouse LD50 oral 97mg/kg (97mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 488, 1950.
mouse LD50 subcutaneous 41mg/kg (41mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
rabbit LD50 intravenous 9mg/kg (9mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946.
rabbit LD50 subcutaneous 33mg/kg (33mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946.
rat LD50 intravenous 12mg/kg (12mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946.
rat LD50 oral 469mg/kg (469mg/kg)   Journal of Pharmaceutical Sciences. Vol. 69, Pg. 1198, 1980.
rat LD50 subcutaneous 75mg/kg (75mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 708, 1951.