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Substance Name: Dexamethasone propionate [JAN]
RN: 15423-89-9
InChIKey: ITYMTTQVNYAJAA-OCUNRLNVSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C25-H33-F-O6

Molecular Weight

  • 448.5277
 
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Names and Synonyms

Name of Substance

  • Dexamethasone 17-propionate
  • Dexamethasone propionate [JAN]

Synonyms

  • Dexamethasone 17-propionate
  • Dexamethasone propionate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, 17-propionate

Systematic Name

  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-, (11-beta,16-alpha)-

Registry Numbers

CAS Registry Number

  • 15423-89-9

System Generated Number

  • 0015423899

Structure Descriptors

InChI

1S/C25H33FO6/c1-5-21(31)32-25(20(30)13-27)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,26)19(29)12-23(18,25)4/h8-9,11,14,17-19,27,29H,5-7,10,12-13H2,1-4H3/t14-,17+,18+,19+,22+,23+,24+,25+/m1/s1

InChIKey

ITYMTTQVNYAJAA-OCUNRLNVSA-N

Smiles

CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rabbit LD50 subcutaneous 7600ug/kg (7.6mg/kg)   Drugs in Japan Vol. -, Pg. 781, 1995.
rat LD50 intraperitoneal 36500mg/kg (36500mg/kg)   Drugs in Japan Vol. -, Pg. 666, 1990.
rat LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. -, Pg. 666, 1990.
rat LD50 subcutaneous 26mg/kg (26mg/kg)   Drugs in Japan Vol. -, Pg. 666, 1990.