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Substance Name: Efavirenz [USP:INN:BAN]
RN: 154598-52-4
UNII: JE6H2O27P8
InChIKey: XPOQHMRABVBWPR-ZDUSSCGKSA-N

Note

  • HIV-1 reverse transcriptase inhibitor.

Molecular Formula

  • C14-H9-Cl-F3-N-O2

Molecular Weight

  • 315.677
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral Agents
  • Cytochrome P-450 CYP2B6 Inducers
  • Cytochrome P-450 CYP2C19 Inhibitors
  • Cytochrome P-450 CYP2C9 Inhibitors
  • Cytochrome P-450 CYP3A Inducers
  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Metabolic Side Effects of Drugs and Substances
  • Non-Nucleoside Reverse Transcriptase Inhibitor
  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors

Names and Synonyms

Name of Substance

  • Efavirenz
  • Efavirenz [USP:INN:BAN]

Synonyms

  • (4s)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2h-3,1-benzoxazin-2-one
  • (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • (S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
  • (S)-Efavirenz
  • DMP 266
  • DMP-266
  • Efavirenz
  • Efavirenz, (S)
  • EFV
  • HSDB 7163
  • L 743726
  • Stocrin
  • Sustiva
  • UNII-JE6H2O27P8

Systematic Name

  • 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-

Registry Numbers

CAS Registry Number

  • 154598-52-4

FDA UNII

  • JE6H2O27P8

System Generated Number

  • 0154598524

Structure Descriptors

InChI

1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1

InChIKey

XPOQHMRABVBWPR-ZDUSSCGKSA-N

Smiles

c1c(Cl)cc2[C@@](OC(Nc2c1)=O)(C#CC1CC1)C(F)(F)F