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Substance Name: Ro 47-3359
RN: 155144-64-2
InChIKey: SSMFYBHQLFTJSA-UHFFFAOYSA-N

Note

  • Inhibits DNA relaxation catalyzed by topoisomerase II and enhances DNA cleavage by the same enzyme.

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors

Molecular Formula

  • C20-H17-F-N4-O3

Molecular Weight

  • 380.377
 
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Names and Synonyms

Name of Substance

  • Ro 47-3359

Synonyms

  • 5-Cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-8-fluoro-2-hydroxypyrimido(1,6-a)benzimidazole-1,3(2H,5H)-dione
  • 5-Cyclopropyl-7-(2,6-dimethyl-4-pyridiyl)-8-fluoro-2-hydroxypyrimido(1,6-a)benzimidazole-1,3(2H,5H)-dione
  • CCRIS 8211
  • Ro-47-3359

Systematic Names

  • Pyrimido(1,6-a)benzimidazole-1,3(2H,5H)-dione, 5-cyclopropyl-7-(2,6-dimethyl-4-pyridinyl)-8-fluoro-2-hydroxy-
  • Pyrimido(1,6-a)benzimidazole-1,3(2H,5H)-dione, 5-cyclopropyl-7-(2,6-dimethyl-4-pyridiyl)-8-fluoro-2-hydroxy-

Registry Numbers

CAS Registry Number

  • 155144-64-2

System Generated Number

  • 0155144642

Structure Descriptors

InChI

1S/C20H17FN4O3/c1-10-5-12(6-11(2)22-10)14-7-16-17(8-15(14)21)24-18(23(16)13-3-4-13)9-19(26)25(28)20(24)27/h5-9,13,28H,3-4H2,1-2H3

InChIKey

SSMFYBHQLFTJSA-UHFFFAOYSA-N

Smiles

c1(cc2n(c3cc(c4cc(nc(c4)C)C)c(F)cc3n2c(n1O)=O)C1CC1)=O