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Substance Name: Methixene hydrochloride anhydrous
RN: 1553-34-0
UNII: FRK5BSL54S
InChIKey: RSXZRFHNNTTWCB-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C20-H23-N-S.Cl-H

Molecular Weight

  • 345.9356
 
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Names and Synonyms

Name of Substance

  • Methixene hydrochloride anhydrous

Synonyms

  • 1-Methyl-3-(thioxanthen-9-ylmethyl)-1-piperidine hydrochloride
  • 1-Pipecoline, 3-(thioxanthen-9-yl)methyl-, hydrochloride
  • 9-((N-Methyl-3-piperidyl)methyl)-thioxanthenhydrochlorid
  • 9-((N-Methyl-3-piperidyl)methyl)-thioxanthenhydrochlorid [German]
  • 9-(1'-Methylpiperidine-3'-methyl)thioxanthene hydrochloride
  • 9-(1-Methyl-3-piperidylmethyl)thiaxanthene hydrochloride
  • Contalyl
  • EINECS 216-300-1
  • Methixart
  • Methixene HCl
  • Methixene hydrochloride
  • Metixene hydrochloride
  • N 715
  • NSC 78194
  • Thioxanthene, 9-(1-methyl-3-piperidylmethyl)-, hydrochloride
  • Tremaril hydrochloride
  • Tremaril wonder
  • UNII-FRK5BSL54S

Systematic Names

  • Metixene hydrochloride
  • Piperidine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-, hydrochloride (9CI)
  • Piperidine, 1-methyl-3-(thioxanthen-9-ylmethyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 1553-34-0

FDA UNII

  • FRK5BSL54S

Related Registry Number

  • 4969-02-2 (Parent)

System Generated Number

  • 0001553340

Molecular Formulas

Molecular Formula

  • C20-H23-N-S.Cl-H

Molecular Formula Fragments

  • C20-H23-N-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H23NS.ClH/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20;/h2-5,8-11,15,18H,6-7,12-14H2,1H3;1H

InChIKey

RSXZRFHNNTTWCB-UHFFFAOYSA-N

Smiles

CN1CCCC(C1)CC2c3ccccc3Sc4c2cccc4.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 108mg/kg (108mg/kg)   Drugs in Japan Vol. 6, Pg. 824, 1982.
mouse LD50 intravenous 18mg/kg (18mg/kg)   Journal of Pharmaceutical Sciences. Vol. 63, Pg. 568, 1964.
mouse LD50 oral 346mg/kg (346mg/kg)   Drugs in Japan Vol. 6, Pg. 824, 1982.
mouse LD50 subcutaneous 238mg/kg (238mg/kg)   Drugs in Japan Vol. 6, Pg. 824, 1982.
rat LD50 intraperitoneal 295mg/kg (295mg/kg)   Drugs in Japan Vol. 6, Pg. 824, 1982.
rat LD50 intravenous 24mg/kg (24mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 141, Pg. 331, 1963.
rat LD50 oral 1460mg/kg (1460mg/kg)   Drugs in Japan Vol. 6, Pg. 824, 1982.
rat LD50 subcutaneous 1519mg/kg (1519mg/kg)   Drugs in Japan Vol. 6, Pg. 824, 1982.