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Substance Name: Noxytiolin [INN:BAN:DCF]
RN: 15599-39-0
UNII: 4DN3AF1FU6
InChIKey: JLMHZVYLAQPMOZ-UHFFFAOYSA-N

Note

  • Local antibacterial that probably acts by releasing formaldehyde in aqueous solutions. It is used for THERAPEUTIC IRRIGATION of infected body cavities - bladder, peritoneum, etc. and as a spray for burns.

Molecular Formula

  • C3-H8-N2-O-S

Molecular Weight

  • 120.1752
 

Classification Codes

  • Anti-Infective Agents
  • Anti-Infective Agents, Local
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Names and Synonyms

Name of Substance

  • Noxythiolin
  • Noxytiolin [INN:BAN:DCF]

MeSH Heading

  • Noxythiolin

Synonyms

  • 1-(Hydroxymethyl)-3-methyl-2-thiourea
  • BRN 2323080
  • EINECS 239-679-5
  • Gynaflex
  • N-(Hydroxymethyl)-N'-methylthiourea
  • Noxitiolinum
  • Noxitolina
  • Noxitolina [INN-Spanish]
  • Noxyflex S
  • Noxythiolin
  • Noxythioline
  • Noxytiolin
  • Noxytioline
  • Noxytioline [INN-French]
  • Noxytiolinum
  • Noxytiolinum [INN-Latin]
  • Thiourea, N-(hydroxymethyl)-N'-methyl-
  • UNII-4DN3AF1FU6

Systematic Names

  • 1-Hydroxymethyl-3-methyl-2-thiourea
  • Noxytiolin
  • Thiourea, N-(hydroxymethyl)-N'-methyl-
  • Urea, 1-(hydroxymethyl)-3-methyl-2-thio-

Registry Numbers

CAS Registry Number

  • 15599-39-0

FDA UNII

  • 4DN3AF1FU6

System Generated Number

  • 0015599390

Structure Descriptors

InChI

1S/C3H8N2OS/c1-4-3(7)5-2-6/h6H,2H2,1H3,(H2,4,5,7)

InChIKey

JLMHZVYLAQPMOZ-UHFFFAOYSA-N

Smiles

CNC(=S)NCO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 3gm/kg (3000mg/kg)   Merck Index. Vol. 11, Pg. 1064, 1989.
rat LD50 intraperitoneal 2400mg/kg (2400mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA Therapie. Vol. 35, Pg. 409, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 89 deg C   EXP
log P (octanol-water) -1.840 (none)   EST
Water Solubility 1.00E+05 mg/L   EXP
Atmospheric OH Rate Constant 1.58E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.