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Substance Name: p-Aminophenetole
RN: 156-43-4
UNII: 9TSL224ZSE
InChIKey: IMPPGHMHELILKG-UHFFFAOYSA-N

Note

  • Used in the manufacture of acetophenetidin.

Molecular Formula

  • C8-H11-N-O

Molecular Weight

  • 137.181
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • Ethyl p-aminophenol
  • p-Aminophenetole
  • p-Phenetidine
  • Phenetidine

MeSH Heading

  • Phenetidine

Synonyms

  • 1-Amino-4-ethoxybenzene
  • 4-13-00-01017 (Beilstein Handbook Reference)
  • 4-Aminoethoxybenzene
  • 4-Aminophenetole
  • 4-Ethoxyaniline
  • 4-Ethoxybenzenamine
  • AI3-09042
  • Aniline, p-ethoxy-
  • BRN 0606666
  • CCRIS 2878
  • CP 5685
  • EC 205-855-5
  • EINECS 205-855-5
  • NSC 3116
  • p-Aminofenetol
  • p-Aminofenetol [Czech]
  • p-Aminophenetole
  • p-Ethoxyaniline
  • p-Fenetidin
  • p-Fenetidin [Czech]
  • p-Phenetidin
  • p-Phenetidine
  • Phenethidine
  • UNII-9TSL224ZSE

Systematic Names

  • Benzenamine, 4-ethoxy-
  • p-Phenetidine

Superlist Names

  • Benzenamine, 4-ethoxy-
  • p-Phenetidine

Registry Numbers

CAS Registry Number

  • 156-43-4

FDA UNII

  • 9TSL224ZSE

System Generated Number

  • 0000156434

Structure Descriptors

InChI

1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3

InChIKey

IMPPGHMHELILKG-UHFFFAOYSA-N

Smiles

c1(ccc(N)cc1)OCC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 692mg/kg (692mg/kg)   Journal of Medicinal Chemistry. Vol. 17, Pg. 900, 1974.
mouse LD50 oral 530mg/kg (530mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(8), Pg. 50, 1981.
rabbit LD50 oral 7gm/kg (7000mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 215, 1956.
rabbit LD50 skin 2353mg/kg (2353mg/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA

KIDNEY, URETER, AND BLADDER: HEMATURIA
National Technical Information Service. Vol. OTS0555214,
rat LCLo inhalation 487mg/m3/4H (487mg/m3) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
National Technical Information Service. Vol. OTS0546240,
rat LD50 oral 540mg/kg (540mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(1), Pg. 92, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 2.4 deg C   EXP
Boiling Point 254 deg C   EXP
pKa Dissociation Constant 5.2 (none) 28 EXP
log P (octanol-water) 1.24 (none)   EXP
Water Solubility 7510 mg/L 25 EST
Vapor Pressure 0.0105 mm Hg 25 EXP
Henry's Law Constant 1.50E-07 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 9.93E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.