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Substance Name: Phenelzine sulfate [USP]
RN: 156-51-4
UNII: 2681D7P965
InChIKey: RXBKMJIPNDOHFR-UHFFFAOYSA-N

Note

  • One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.

Molecular Formula

  • C8-H12-N2.H2-O4-S

Molecular Weight

  • 234.2746
 

Classification Codes

Classification Codes

  • Antidepressant
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Code

  • Overall Carcinogenic Evaluation: Group 3
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Names and Synonyms

Name of Substance

  • Phenelzine acid sulfate
  • Phenelzine sulfate [USP]

Synonyms

  • 1-Hydrazino-2-phenylethane hydrogen sulphate
  • 2-Phenylethylhydrazine dihydrogen sulfate
  • 2-Phenylethylhydrazine dihydrogen sulphate
  • 2-Phenylethylhydrazine hydrogen sulphate
  • 2-Phenylethylhydrazine sulphate
  • Alacine
  • Alazin
  • Alazine
  • beta-Phenylethylhydrazine dihydrogen sulfate
  • beta-Phenylethylhydrazine hydrogen sulphate
  • beta-Phenylethylhydrazine sulfate
  • CCRIS 498
  • EINECS 205-856-0
  • EP-411
  • Estinerval
  • Hydrazine, (2-phenylethyl)-, sulfate (1:1)
  • Kalgan
  • Mao-Rem
  • N-1544a
  • Nardelzine
  • Nardil
  • NSC 170957
  • P 1531
  • Phenalzine dihydrogen sulfate
  • Phenelzine acid sulfate
  • Phenelzine bisulfate
  • Phenelzine bisulphate
  • Phenelzine dihydrogen sulfate
  • Phenelzine hydrogen sulfate
  • Phenelzine sulfate
  • Phenelzine sulphate
  • Phenethylhydrazin
  • Phenethylhydrazine sulfate
  • Phenethylhydrazine sulfate (1:1)
  • Phenethylhydrazine sulphate
  • Phenodyne
  • Phenylethylhydrazine dihydrogen sulphate
  • Phenylethylhydrazine sulphate
  • S 1544
  • Stinerval
  • UNII-2681D7P965
  • W 1544A
  • WL 7

Systematic Names

  • Hydrazine, (2-phenylethyl)-, sulfate (1:1)
  • Hydrazine, phenethyl-, sulfate (1:1)
  • Phenelzine hydrogen sulphate
  • Phenelzine sulfate

Superlist Name

  • Phenelzine sulphate

Registry Numbers

CAS Registry Number

  • 156-51-4

FDA UNII

  • 2681D7P965

Other Registry Number

  • 75513-79-0

System Generated Number

  • 0000156514

Molecular Formulas

Molecular Formula

  • C8-H12-N2.H2-O4-S

Molecular Formula Fragments

  • C8-H12-N2
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)

InChIKey

RXBKMJIPNDOHFR-UHFFFAOYSA-N

Smiles

c1ccc(cc1)CCNN.OS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 77mg/kg/17W-I (77mg/kg) LIVER: OTHER CHANGES Annals of Internal Medicine. Vol. 124, Pg. 692, 1996.
man TDLo oral 46mg/kg/10W-I (46mg/kg) LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
American Journal of Medicine. Vol. 80, Pg. 689, 1986.
man TDLo oral 626mg/kg/2Y-I (626mg/kg) PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH

PERIPHERAL NERVE AND SENSATION: PARESTHESIS

PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE
Australian and New Zealand Journal of Medicine. Vol. 21, Pg. 339, 1991.
mouse LD50 intraperitoneal 162mg/kg (162mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal of Medicinal Chemistry. Vol. 18, Pg. 20, 1975.
mouse LD50 intravenous 157mg/kg (157mg/kg)   Annals of the New York Academy of Sciences. Vol. 107, Pg. 899, 1963.
mouse LD50 oral 156mg/kg (156mg/kg)   Annals of the New York Academy of Sciences. Vol. 107, Pg. 899, 1963.
mouse LD50 subcutaneous 125mg/kg (125mg/kg)   Journal of Endocrinology. Vol. 30, Pg. 205, 1964.
rabbit LD50 intraperitoneal 70mg/kg (70mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 25, Pg. 158, 1965.
rat LD50 intraperitoneal 250mg/kg (250mg/kg)   Acta Biologica et Medica Germanica. Vol. 18, Pg. 617, 1967.
rat LD50 oral 210mg/kg (210mg/kg)   Annals of the New York Academy of Sciences. Vol. 107, Pg. 899, 1963.
women LDLo oral 30mg/kg (30mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LIVER: FATTY LIVER DEGERATION
Journal of Analytical Toxicology. Vol. 19, Pg. 265, 1995.
women TDLo oral 18mg/kg (18mg/kg)   Anaesthesia. Vol. 41, Pg. 53, 1986.
women TDLo oral 18mg/kg (18mg/kg) BLOOD: OTHER CHANGES

BEHAVIORAL: COMA
Anaesthesia. Vol. 41, Pg. 53, 1986.
women TDLo oral 3615mg/kg/11Y (3615mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

PERIPHERAL NERVE AND SENSATION: PARESTHESIS
American Journal of Medicine. Vol. 75, Pg. 887, 1983.