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Substance Name: Molindone hydrochloride [USAN:USP]
RN: 15622-65-8
UNII: 1DWS68PNE6
InChIKey: GQWNECFJGBQMBO-UHFFFAOYSA-N

Note

  • An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)

Molecular Formula

  • C16-H24-N2-O2.Cl-H

Molecular Weight

  • 312.8385
 

Classification Codes

  • Antipsychotic
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Molindone hydrochloride [USAN:USP]

Synonyms

  • 3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one monohydrochloride
  • 3-Ethyl-6,7-dihydro-2-methyl-5-morpholinomethylindol-4(5H)-one hydrochloride
  • EN 1733 A
  • EN-1733A
  • Lidone
  • Moban
  • Molindone HCl
  • Molindone hydrochloride
  • UNII-1DWS68PNE6

Systematic Names

  • 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-, monohydrochloride
  • Indol-4(5H)-one, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 15622-65-8

FDA UNII

  • 1DWS68PNE6

Related Registry Number

  • 7416-34-4 (Parent)

System Generated Number

  • 0015622658

Molecular Formulas

Molecular Formula

  • C16-H24-N2-O2.Cl-H

Molecular Formula Fragments

  • C16-H24-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H

InChIKey

GQWNECFJGBQMBO-UHFFFAOYSA-N

Smiles

Cl.CCc1c(C)[nH]c2CCC(CN3CCOCC3)C(=O)c12

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 4762ug/kg/3D- (4.762mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

MUSCULOSKELETAL: OTHER CHANGES
Journal of Clinical Psychiatry. Vol. 47, Pg. 607, 1986.
mouse LD50 intraperitoneal 243mg/kg (243mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 134, 1972.
mouse LD50 oral 670mg/kg (670mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 26, Pg. 738, 1967.
rat LD50 oral 261mg/kg (261mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.