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Substance Name: Peroxisomicine a2
RN: 156768-16-0
UNII: 5WSH25U3R5
InChIKey: FBPZAGOTWAVQJH-XZWHSSHBSA-N

Note

  • Cytotoxic hydroxyanthracenone from fruits of Karwinskia parvifolia (Rhamnaceae).

Classification Code

  • Natural Product

Molecular Formula

  • C30-H26-O8

Molecular Weight

  • 514.5274
 
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Names and Synonyms

Name of Substance

  • Peroxisomicine A2

Synonyms

  • Diast T-514
  • Peroxisomicin A2
  • Peroxisomicine A2
  • T 514'
  • UNII-5WSH25U3R5

Systematic Name

  • (2,9'-Bianthracene-4',8(1'H,5H)-dione, 2',3',6,7-tetrahydro-2',6-dimethyl-1,2',5',6,9,10'-hexahydroxy-

Registry Numbers

CAS Registry Number

  • 156768-16-0

FDA UNII

  • 5WSH25U3R5

System Generated Number

  • 0156768160

Structure Descriptors

InChI

1S/C30H26O8/c1-29(37)9-14-8-13-6-7-16(26(34)22(13)27(35)21(14)19(32)11-29)23-15-4-3-5-18(31)24(15)28(36)25-17(23)10-30(2,38)12-20(25)33/h3-8,31,34-38H,9-12H2,1-2H3/t29-,30+/m0/s1

InChIKey

FBPZAGOTWAVQJH-XZWHSSHBSA-N

Smiles

C[C@@]1(Cc2cc3ccc(c(c3c(c2C(=O)C1)O)O)c4c5cccc(c5c(c6c4C[C@@](CC6=O)(C)O)O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 31600ug/kg (31.6mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI
Toxicology Letters. Vol. 90, Pg. 155, 1997.
mouse LD50 oral 61500ug/kg (61.5mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI
Toxicology Letters. Vol. 90, Pg. 155, 1997.