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Substance Name: Orgotein
RN: 1569268-91-2
UNII: PKE82W49V1
InChIKey: TUGDLVFMIQZYPA-UHFFFAOYSA-N

Note

  • Mainly alpha-helical partly divalent metal (Mg,Cu,Zn) chelated water soluble protein (MW-34000) from bovine liver; for treatment of cystitis; has superoxide dismutase activity.

Molecular Formula

  • Unspecified

Molecular Weight

  • 515.744
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Orgotein

Synonyms

  • Bovine copper-zinc superoxide dismutase
  • Ontosein
  • Orgotein
  • Orgotein [GREEN BOOK]
  • Orgotein [INN]
  • Orgotein [MART.]
  • Orgotein [USAN]
  • Orgotein [WHO-DD]
  • Orgotein, bovine
  • Ormetein
  • Palosein
  • Superoxide dismutase (bovine)
  • Superoxide dismutase, bovine (Cu-Zn)
  • UNII-PKE82W49V1

Systematic Name

  • Copper-zinc superoxide dismutase

Registry Numbers

CAS Registry Number

  • 1569268-91-2

FDA UNII

  • PKE82W49V1

Other Registry Numbers

  • 11118-62-0
  • 37294-21-6
  • 9016-01-7

System Generated Number

  • 1569268912

Structure Descriptors

InChI

1S/4Cu.4Zn/q8*+2

InChIKey

TUGDLVFMIQZYPA-UHFFFAOYSA-N

Smiles

[Cu+2].[Cu+2].[Cu+2].[Cu+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD subcutaneous > 100mg/kg (100mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
monkey LD intramuscular > 60mg/kg (60mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
monkey LD intravenous > 100mg/kg (100mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
mouse LD oral > 5500mg/kg (5500mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
mouse LD subcutaneous > 5500mg/kg (5500mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
mouse LD50 intravenous 4435mg/kg (4435mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
mouse LDLo intraperitoneal 60mg/kg (60mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

GASTROINTESTINAL: PERITONITIS

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
Toxicology and Applied Pharmacology. Vol. 26, Pg. 184, 1973.
rabbit LD subcutaneous > 40mg/kg (40mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
rabbit LDLo intravenous 10mg/kg (10mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Toxicology and Applied Pharmacology. Vol. 26, Pg. 184, 1973.
rat LD intraperitoneal > 5500mg/kg (5500mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
rat LD oral > 5500mg/kg (5500mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
rat LD subcutaneous > 5500mg/kg (5500mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.
rat LD50 intravenous 4435mg/kg (4435mg/kg)   European Journal of Rheumatology and Inflammation. Vol. 4, Pg. 173, 1981.