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Substance Name: Olsalazine [INN:BAN]
RN: 15722-48-2
UNII: ULS5I8J03O
InChIKey: QQBDLJCYGRGAKP-FOCLMDBBSA-N

Note

  • Cpd with 2 salicylate molecules linked together by an azo bond; when given orally, liberates 5-aminosalicylic acid in colonic lumen; potential for treatment of ulcerative colitis; confusing synonym sodium diazosalicylate from letter in JAMA 1982;248(8):924.

Molecular Formula

  • C14-H10-N2-O6

Molecular Weight

  • 302.241
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Human Data
  • Peripheral Nervous System Agents
  • Sensory System Agents

Names and Synonyms

Name of Substance

  • Olsalazine
  • Olsalazine [INN:BAN]

Synonyms

  • 3,3'-Azobis(6-hydroxybenzoic acid)
  • 5,5'-Azobis(salicylic acid)
  • Azodisal
  • C.I. Mordant Yellow 5
  • Dipentium
  • Olsalazina
  • Olsalazina [Spanish]
  • Olsalazine
  • Olsalazinum
  • Olsalazinum [Latin]
  • Rasal
  • Salicylic acid, 5,5'-azodi-
  • UNII-ULS5I8J03O

Systematic Names

  • Benzoic acid, 3,3'-azobis(6-hydroxy-
  • Benzoic acid, 3,3'-azobis(6-hydroxy-, disodium salt

Registry Numbers

CAS Registry Number

  • 15722-48-2

FDA UNII

  • ULS5I8J03O

Related Registry Number

  • 6054-98-4 (di-hydrochloride salt)

System Generated Number

  • 0015722482

Structure Descriptors

InChI

InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+

InChIKey

QQBDLJCYGRGAKP-FOCLMDBBSA-N

Smiles

OC(=O)c1cc(ccc1O)\N=N\c2ccc(O)c(c2)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 1714mg/kg/34W (1714mg/kg) KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS American Journal of Medicine. Vol. 100, Pg. 238, 1996.