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Substance Name: Olsalazine [INN:BAN]
RN: 15722-48-2
UNII: ULS5I8J03O
InChIKey: QQBDLJCYGRGAKP-FOCLMDBBSA-N
Note
- Cpd with 2 salicylate molecules linked together by an azo bond; when given orally, liberates 5-aminosalicylic acid in colonic lumen; potential for treatment of ulcerative colitis; confusing synonym sodium diazosalicylate from letter in JAMA 1982;248(8):924.
Molecular Formula
- C14-H10-N2-O6
Molecular Weight
- 302.241
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Gastrointestinal Agents
- Human Data
- Peripheral Nervous System Agents
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Olsalazine
- Olsalazine [INN:BAN]
Synonyms
- 3,3'-Azobis(6-hydroxybenzoic acid)
- 5,5'-Azobis(salicylic acid)
- Azodisal
- C.I. Mordant Yellow 5
- Dipentium
- Olsalazina
- Olsalazina [Spanish]
- Olsalazine
- Olsalazinum
- Olsalazinum [Latin]
- Rasal
- Salicylic acid, 5,5'-azodi-
- UNII-ULS5I8J03O
Systematic Names
- Benzoic acid, 3,3'-azobis(6-hydroxy-
- Benzoic acid, 3,3'-azobis(6-hydroxy-, disodium salt
Registry Numbers
CAS Registry Number
- 15722-48-2
FDA UNII
- ULS5I8J03O
Related Registry Number
- 6054-98-4 (di-hydrochloride salt)
System Generated Number
- 0015722482
Structure Descriptors
InChI
InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+InChIKey
QQBDLJCYGRGAKP-FOCLMDBBSA-NSmiles
OC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 1714mg/kg/34W (1714mg/kg) | KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS | American Journal of Medicine. Vol. 100, Pg. 238, 1996. |