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Substance Name: Indinavir sulfate [USAN:USP]
RN: 157810-81-6
UNII: 771H53976Q
InChIKey: NUBQKPWHXMGDLP-BDEHJDMKSA-N
Note
- A potent and specific HIV protease inhibitor that appears to have good oral bioavailability.
Molecular Formula
- C36-H47-N5-O4.H2-O4-S
Molecular Weight
- 711.8761
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antiretroviral
- Antiviral
- Protease Inhibitor
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Names and Synonyms
Name of Substance
- Indinavir Sulfate
- Indinavir sulfate [USAN:USP]
MeSH Heading
- Indinavir
Synonyms
- (alphaR,gammaS,2S)-alpha-Benzyl-2-(tert-butylcarbamoyl)-gamma-hydroxy-N-((1S,2R)-2-hydroxy-1-indanyl)-4-(3-pyridylmethyl)-1-piperazinevaleramide sulfate (1:1) (salt)
- Crixivan
- D-erythro-Pentonamide, 2,3,5-trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-, (1(1S,2R,5(S))-, sulfate (1:1) (salt)
- DRG-0233
- HSDB 7158
- IDV
- Indinavir Sulfate
- L 735524
- L-735,524
- MK 639
- MK-639
- NSC 697197
- UNII-771H53976Q
Systematic Names
- D-erythro-Pentonamide, 2,3,5-trideoxy-N-((1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-((2S)-2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-, sulfate (1:1) (salt)
- D-erythro-Pentonamide, 2,3,5-trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-, monohydrate, (1(1S,2R),5(S))-, sulfate (1:1)
Registry Numbers
CAS Registry Number
- 157810-81-6
FDA UNII
- 771H53976Q
Related Registry Number
- 150378-17-9 (Parent)
System Generated Number
- 0157810816
Molecular Formulas
Molecular Formula
- C36-H47-N5-O4.H2-O4-S
Molecular Formula Fragments
- C36-H47-N5-O4
- COMPONENT
- H2-O4-S
Structure Descriptors
InChI
InChI=1S/C36H47N5O4.H2O4S/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43;1-5(2,3)4/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45);(H2,1,2,3,4)/t28-,29+,31+,32-,33+;/m1./s1InChIKey
NUBQKPWHXMGDLP-BDEHJDMKSA-NSmiles
CC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intraperitoneal | > 640mg/kg (640mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 2167, 1997. |
dog | LD50 | oral | > 640mg/kg (640mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 2167, 1997. |
mouse | LD50 | intraperitoneal | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 2167, 1997. | |
mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 2167, 1997. | |
rat | LD50 | intraperitoneal | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 2167, 1997. | |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 2167, 1997. |