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Substance Name: Cromolyn sodium [USAN:USP]
RN: 15826-37-6
UNII: Q2WXR1I0PK
InChIKey: VLARUOGDXDTHEH-UHFFFAOYSA-L

Note

  • A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

Molecular Formulas

  • C23-H14-Na2-O11
  • C23-H14-O11.2Na
  • C23-H16-O11.2Na

Molecular Weight

  • 512.3326
 

Classification Codes

  • Anti-Asthmatic (Prophylactic)
  • Anti-Asthmatic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Respiratory System Agents
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Names and Synonyms

Name of Substance

  • Cromolyn sodium
  • Cromolyn sodium [USAN:USP]

MeSH Heading

  • Cromolyn sodium

Synonyms

  • 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, disodium salt)
  • 5,5'-((2-Hydroxytrimethylene)dioxy)bis(4-oxo-4H-1-benzopyran-2-carboxylic acid) disodium salt
  • Aarane
  • Aararre
  • CCRIS 3194
  • Crolom
  • Cromo asma aerosol
  • Cromoglicinsaeure, dinatriumsalz
  • Cromoglycate disodium
  • Cromolyn sodium
  • Cromoptic
  • Dinatrium cromoglicicum
  • Dinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan
  • Dinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan [German]
  • Disodium 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4H-1-benzopyran-2-carboxylate)
  • Disodium cromoglycate
  • EINECS 239-926-7
  • FPL 670
  • FPL.670
  • Frenasma
  • Gastrocrom
  • Gastrofrenal
  • Inostral
  • Inostral (Anti-asthmatic)
  • Intal
  • Intal nebulizer
  • Lomuda
  • Lomudal
  • Lomudas
  • Lomusol
  • Nalcrom
  • Nasalcrom
  • Nasmil
  • Natrii cromoglicas
  • Natrium cromoglicat
  • Natrium cromoglicat [German]
  • Nebulasma
  • NSC 109500
  • Opticrom
  • Rynacrom
  • Sodium cromoglicate
  • Sodium cromoglycate
  • Sodium cromolyn
  • UNII-Q2WXR1I0PK

Systematic Names

  • 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, disodium salt
  • 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-, disodium salt
  • Chromolyn sodium
  • Disodium 5,5'-((2-hydroxytrimethylene)bis(oxy))bis(4-oxo-4H-1-benzopyran-2-carboxylate)

Registry Numbers

CAS Registry Number

  • 15826-37-6

FDA UNII

  • Q2WXR1I0PK

Other Registry Numbers

  • 105878-73-7
  • 87016-01-1
  • 93356-84-4

Related Registry Number

  • 16110-51-3 (Cromolyn)

System Generated Number

  • 0015826376

Molecular Formulas

Molecular Formulas

  • C23-H14-Na2-O11
  • C23-H14-O11.2Na
  • C23-H16-O11.2Na

Molecular Formula Fragments

  • C23-H14-O11
  • C23-H16-O11
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C23H16O11.2Na/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2

InChIKey

VLARUOGDXDTHEH-UHFFFAOYSA-L

Smiles

c1cc2c(c(c1)OCC(COc3cccc4c3c(=O)cc(o4)C(=O)[O-])O)c(=O)cc(o2)C(=O)[O-].[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 1600mg/kg (1600mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
dog LD50 oral > 4gm/kg (4000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
human TDLo oral 34mg/kg/4W (34mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
British Medical Journal. Vol. 2, Pg. 916, 1976.
mammal (species unspecified) LD50 intravenous 1001mg/kg (1001mg/kg)   United States Patent Document. Vol. #4238495,
mouse LD50 intraperitoneal 1gm/kg (1000mg/kg)   Planta Medica. Vol. 42, Pg. 75, 1981.
mouse LD50 intravenous 3300mg/kg (3300mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
mouse LD50 oral > 11gm/kg (11000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
mouse LD50 subcutaneous 4400mg/kg (4400mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
rabbit LD50 intravenous 2gm/kg (2000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
rabbit LD50 oral > 8gm/kg (8000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
rat LD50 intraperitoneal > 4gm/kg (4000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
rat LD50 intravenous > 4gm/kg (4000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
rat LD50 oral > 11gm/kg (11000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
rat LD50 subcutaneous 6gm/kg (6000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 189, 1970.
women TDLo oral 96mg/kg/6D-I (96mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 289, Pg. 470, 1984.