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Substance Name: Chloralose [INN:DCF]
RN: 15879-93-3
UNII: 238BZ29MUE
InChIKey: OJYGBLRPYBAHRT-IPQSZEQASA-N

Note

  • A derivative of CHLORAL HYDRATE that was used as a sedative but has been replaced by safer and more effective drugs. Its most common use is as a general anesthetic in animal experiments.

Molecular Formula

  • C8-H11-Cl3-O6

Molecular Weight

  • 309.5279
 

Classification Codes

  • Agricultural Chemical
  • Anesthetics
  • Anesthetics, General
  • Anesthetics, Intravenous
  • Avicide
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Hypnotics and Sedatives
  • Rodenticide
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Chloralose
  • Chloralose [BSI:ISO]
  • Chloralose [INN:DCF]
  • Glucochloralose [BSI:ISO]

MeSH Heading

  • Chloralose

Synonyms

  • (R)-1,2-O-(2,2,2-Trichloroethylidene)-alpha-D-glucofuranose
  • 1,2-O-(2,2,2-Trichloroethylidene)-alpha-D-glucofuranose
  • 4-19-00-04906 (Beilstein Handbook Reference)
  • AGC
  • Alfamat
  • alpha-Chloralose
  • alpha-D-Glucochloralose
  • Alphachloralose
  • Alphakil
  • Anhydroglucochloral
  • Aphosal
  • BRN 0085418
  • Caswell No. 876AA
  • Chloralosane
  • Chloralose
  • Chloralosum
  • Chloralosum [INN-Latin]
  • Chloroalosane
  • Cloralosa
  • Cloralosa [INN-Spanish]
  • Dorcalm
  • Dulcidor
  • EINECS 240-016-7
  • EPA Pesticide Chemical Code 476200
  • Glucochloral
  • Glucochloral [ISO-French]
  • Glucochloralose
  • Kalmettumsomniferum
  • Krakalos
  • Monotrichlor-aethyliden-alpha-glucose
  • Monotrichlor-aethyliden-alpha-glucose [German]
  • Murex
  • Perglucorat
  • Somio
  • UNII-238BZ29MUE

Systematic Names

  • alpha-D-Glucofuranose, 1,2-O-((1R)-2,2,2-trichloroethylidene)-
  • alpha-D-Glucofuranose, 1,2-O-(2,2,2-trichloroethylidene)-, (R)- (9CI)
  • alpha-D-Glucofuranose, 1,2-O-(2,2,2-trichloroethylidene)-, (theta)-
  • Chloralose

Registry Numbers

CAS Registry Number

  • 15879-93-3

FDA UNII

  • 238BZ29MUE

Other Registry Number

  • 910889-31-5

System Generated Number

  • 0015879933

Structure Descriptors

InChI

1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1

InChIKey

OJYGBLRPYBAHRT-IPQSZEQASA-N

Smiles

OC[C@@H](O)[C@H]1O[C@@H]2O[C@@H](O[C@@H]2[C@H]1O)C(Cl)(Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - domestic LD50 intraperitoneal 200mg/kg (200mg/kg)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A012, Pg. 1984,
bird - domestic LD50 oral 32mg/kg (32mg/kg)   Pesticide Manual. Vol. 9, Pg. 135, 1991.
bird - wild LD50 oral 9mg/kg (9mg/kg)   Journal de Toxicologie Clinique et Experimentale. Vol. 6(3), Pg. 175, 1986.
cat LD50 oral 250mg/kg (250mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
cat LDLo intraperitoneal 150mg/kg (150mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 3, Pg. 191, 1897.
chicken LD50 oral 300mg/kg (300mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Wildlife Diseases. Vol. 24, Pg. 684, 1988.
dog LD50 oral 250mg/kg (250mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.
dog LDLo intraperitoneal 400mg/kg (400mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 3, Pg. 191, 1897.
dog LDLo intravenous 120mg/kg (120mg/kg)   "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A012, Pg. 1984,
duck LD50 oral 42mg/kg (42mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
man LDLo oral 214mg/kg (214mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LIVER: OTHER CHANGES
Forensic Science International. Vol. 104, Pg. 59, 1999.
mouse LD50 intraperitoneal 175mg/kg (175mg/kg) BEHAVIORAL: ANALGESIA

BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1727, 1971.
mouse LD50 oral 200mg/kg (200mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C68, 1991.
pigeon LD50 oral 178mg/kg (178mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
quail LD50 oral 31600ug/kg (31.6mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rat LD50 oral 400mg/kg (400mg/kg)   Pesticide Manual. Vol. 9, Pg. 135, 1991.
rat LDLo subcutaneous 200mg/kg (200mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 70, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 182-184 deg C   EXP
log P (octanol-water) 1.02 (none)   EXP
Water Solubility 4440 mg/L 15 EXP
Vapor Pressure 2.81E-09 mm Hg 25 EST
Henry's Law Constant 9.62E-17 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 4.02E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.