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Substance Name: Everolimus [USAN:INN:BAN]
RN: 159351-69-6
UNII: 9HW64Q8G6G
InChIKey: HKVAMNSJSFKALM-GKUWKFKPSA-N
Notes
- A derivative of sirolimus and an inhibitor of TOR SERINE-THREONINE KINASES. It is used to prevent GRAFT REJECTION in heart and kidney transplant patients by blocking cell proliferation signals. It is also an ANTINEOPLASTIC AGENT.
- A rapamycin analog.
NCI: A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI Thesaurus)
Molecular Formula
- C53-H83-N-O14
Molecular Weight
- 958.2317
Classification Codes
- Antineoplastic Agents
- Immunologic Factors
- Immunosuppressant
- Immunosuppressive Agents
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Names and Synonyms
Name of Substance
- Everolimus
- Everolimus [USAN:INN:BAN]
MeSH Heading
- Everolimus
Synonyms
- (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
- (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
- 40-O-(2-hydroxyethyl)-rapamycin
- 42-O-(2-Hydroxyethyl)rapamycin
- Afinitor
- Afinitor Disperz
- Certican
- Everolimus
- HSDB 8255
- RAD
- RAD 001
- RAD001
- SDZ RAD
- SDZ-RAD
- UNII-9HW64Q8G6G
- Xience V
- Zortress
Systematic Names
- (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone
- Rapamycin, 42-O-(2-hydroxyethyl)-
Registry Numbers
CAS Registry Number
- 159351-69-6
FDA UNII
- 9HW64Q8G6G
Other Registry Number
- 1245613-55-1
System Generated Number
- 0159351696