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Substance Name: Fomivirsen sodium [USAN]
RN: 160369-77-7
UNII: 3Z6W3S36X5
InChIKey: DLKYYJFLRUUGHJ-SSJCJZGYSA-A

Note

  • An antisense compound; used to treat CMV retinitis in patients with AIDS.

Classification Code

  • Antisense Antiviral used in the Therapy of Cytomegalovirus Retinitis

Molecular Formulas

  • C204-H263-N63-O114-P20-S20.20-Na
  • C204-H263-N63-O114-P20-S20.20Na

Molecular Weight

  • 7122.0907
 
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Names and Synonyms

Name of Substance

  • Fomivirsen sodium
  • Fomivirsen sodium [USAN]

Synonyms

  • 2'-Deoxy-P-thioguanylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-2'-deoxy-P-thioguanylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thioguanylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thiothymidylyl-(5'-3')-2'-deoxy-P-thioguanylyl-(5'-3')-2'-deoxy-P-thiocytidylyl-(5'-3')-2'-deoxyguanosine, eicosasodium salt
  • Deoxyribonucleic acid d(P-thio)(G-C-G-T-T-T-G-C-T-C-T-T-C-T-T-C-T-T-G-C-G), eicosasodium salt
  • Fomivirsen sodium
  • ISIS 2922
  • ISIS-2922
  • UNII-3Z6W3S36X5
  • Vitravene
  • Vitravene preservative free

Systematic Name

  • DNA, d(P-thio)(G-C-G-T-T-T-G-C-T-C-T-T-C-T-T-C-T-T-G-C-G), eicosasodium salt

Superlist Name

  • DRG-0234

Registry Numbers

CAS Registry Number

  • 160369-77-7

FDA UNII

  • 3Z6W3S36X5

System Generated Number

  • 0160369777

Molecular Formulas

Molecular Formulas

  • C204-H263-N63-O114-P20-S20.20-Na
  • C204-H263-N63-O114-P20-S20.20Na

Molecular Formula Fragments

  • C204-H263-N63-O114-P20-S20
  • COMPONENT
  • Na

Structure Descriptors

InChI

InChI=1S/C204H263N63O114P20S20.20Na/c1-80-44-253(195(291)237-169(80)270)145-31-98(119(349-145)62-328-387(306,407)367-97-30-144(252-22-16-137(210)226-194(252)290)348-118(97)61-327-400(319,420)380-109-42-157(266-78-219-162-167(266)230-187(214)235-182(162)283)361-131(109)74-340-398(317,418)378-107-40-154(262-53-89(10)178(279)246-204(262)300)357-127(107)70-336-395(314,415)375-104-37-151(259-50-86(7)175(276)243-201(259)297)355-125(104)68-334-396(315,416)376-105-38-152(260-51-87(8)176(277)244-202(260)298)358-128(105)71-337-401(320,421)381-110-43-158(267-79-220-163-168(267)231-188(215)236-183(163)284)359-129(110)72-338-388(307,408)368-93-26-140(248-18-12-133(206)222-190(248)286)343-113(93)56-322-383(302,403)362-91-24-155(341-111(91)54-268)264-76-217-160-165(264)228-185(212)233-180(160)281)369-389(308,409)323-58-115-94(27-141(345-115)249-19-13-134(207)223-191(249)287)364-384(303,404)329-63-120-101(34-148(350-120)256-47-83(4)172(273)240-198(256)294)372-392(311,412)332-66-123-99(32-146(353-123)254-45-81(2)170(271)238-196(254)292)370-390(309,410)324-59-116-95(28-142(346-116)250-20-14-135(208)224-192(250)288)365-385(304,405)330-64-121-102(35-149(351-121)257-48-84(5)173(274)241-199(257)295)373-393(312,413)333-67-124-100(33-147(354-124)255-46-82(3)171(272)239-197(255)293)371-391(310,411)325-60-117-96(29-143(347-117)251-21-15-136(209)225-193(251)289)366-386(305,406)331-65-122-103(36-150(352-122)258-49-85(6)174(275)242-200(258)296)374-394(313,414)335-69-126-106(39-153(356-126)261-52-88(9)177(278)245-203(261)299)377-397(316,417)339-73-130-108(41-156(360-130)265-77-218-161-166(265)229-186(213)234-181(161)282)379-399(318,419)326-57-114-92(25-139(344-114)247-17-11-132(205)221-189(247)285)363-382(301,402)321-55-112-90(269)23-138(342-112)263-75-216-159-164(263)227-184(211)232-179(159)280;;;;;;;;;;;;;;;;;;;;/h11-22,44-53,75-79,90-131,138-158,268-269H,23-43,54-74H2,1-10H3,(H,301,402)(H,302,403)(H,303,404)(H,304,405)(H,305,406)(H,306,407)(H,307,408)(H,308,409)(H,309,410)(H,310,411)(H,311,412)(H,312,413)(H,313,414)(H,314,415)(H,315,416)(H,316,417)(H,317,418)(H,318,419)(H,319,420)(H,320,421)(H2,205,221,285)(H2,206,222,286)(H2,207,223,287)(H2,208,224,288)(H2,209,225,289)(H2,210,226,290)(H,237,270,291)(H,238,271,292)(H,239,272,293)(H,240,273,294)(H,241,274,295)(H,242,275,296)(H,243,276,297)(H,244,277,298)(H,245,278,299)(H,246,279,300)(H3,211,227,232,280)(H3,212,228,233,281)(H3,213,229,234,282)(H3,214,230,235,283)(H3,215,231,236,284);;;;;;;;;;;;;;;;;;;;/q;20*+1/p-20/t90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111+,112+,113+,114+,115+,116+,117+,118+,119+,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,138+,139+,140+,141+,142+,143+,144+,145+,146+,147+,148+,149+,150+,151+,152+,153+,154+,155+,156+,157+,158+,382?,383?,384?,385?,386?,387?,388?,389?,390?,391?,392?,393?,394?,395?,396?,397?,398?,399?,400?,401?;;;;;;;;;;;;;;;;;;;;/m0..................../s1

InChIKey

DLKYYJFLRUUGHJ-SSJCJZGYSA-A

Smiles

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CN([C@H]2C[C@H](OP(=O)([S-])OC[C@H]3O[C@H](C[C@@H]3OP(=O)([S-])OC[C@H]4O[C@H](C[C@@H]4OP(=O)([S-])OC[C@H]5O[C@H](C[C@@H]5OP(=O)([S-])OC[C@H]6O[C@H](C[C@@H]6OP(=O)([S-])OC[C@H]7O[C@H](C[C@@H]7OP(=O)([S-])OC[C@H]8O[C@H](C[C@@H]8OP(=O)([S-])OC[C@H]9O[C@H](C[C@@H]9OP(=O)([S-])OC[C@H]%10O[C@H](C[C@@H]%10OP(=O)([S-])OC[C@H]%11O[C@H](C[C@@H]%11OP(=O)([S-])OC[C@H]%12O[C@H](C[C@@H]%12OP(=O)([S-])OC[C@H]%13O[C@H](C[C@@H]%13OP(=O)([S-])OC[C@H]%14O[C@H](C[C@@H]%14OP(=O)([S-])OC[C@H]%15O[C@H](C[C@@H]%15OP(=O)([S-])OC[C@H]%16O[C@H](C[C@@H]%16OP(=O)([S-])OC[C@H]%17O[C@H](C[C@@H]%17OP(=O)([S-])OC[C@H]%18O[C@H](C[C@@H]%18O)n%19cnc%20C(=O)NC(=Nc%19%20)N)N%21C=CC(=NC%21=O)N)n%22cnc%23C(=O)NC(=Nc%22%23)N)N%24C=C(C)C(=O)NC%24=O)N%25C=C(C)C(=O)NC%25=O)N%26C=CC(=NC%26=O)N)N%27C=C(C)C(=O)NC%27=O)N%28C=C(C)C(=O)NC%28=O)N%29C=CC(=NC%29=O)N)N%30C=C(C)C(=O)NC%30=O)N%31C=C(C)C(=O)NC%31=O)N%32C=CC(=NC%32=O)N)N%33C=C(C)C(=O)NC%33=O)N%34C=CC(=NC%34=O)N)n%35cnc%36C(=O)NC(=Nc%35%36)N)N%37C=C(C)C(=O)NC%37=O)[C@@H](COP(=O)([S-])O[C@H]%38C[C@@H](O[C@@H]%38COP(=O)([S-])O[C@H]%39C[C@@H](O[C@@H]%39COP(=O)([S-])O[C@H]%40C[C@@H](O[C@@H]%40COP(=O)([S-])O[C@H]%41C[C@@H](O[C@@H]%41CO)n%42cnc%43C(=O)NC(=Nc%42%43)N)N%44C=CC(=NC%44=O)N)n%45cnc%46C(=O)NC(=Nc%45%46)N)N%47C=C(C)C(=O)NC%47=O)O2)C(=O)NC1=O