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Substance Name: Isosorbide mononitrate [USAN:USP:INN:BAN:JAN]
RN: 16051-77-7
UNII: LX1OH63030
InChIKey: YWXYYJSYQOXTPL-SLPGGIOYSA-N

Note

  • For prevention of angina pectoris; a Russian drug.

Molecular Formula

  • C6-H9-N-O6

Molecular Weight

  • 191.138
 

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Nitric Oxide Donors
  • Reproductive Effect
  • Vasodilator (Coronary)
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Isosorbide mononitrate [USAN:USP:INN:BAN:JAN]
  • Isosorbide-5-mononitrate

Synonyms

  • 1,4:3,6-Dianhydro-D-glucitol 5-nitrate
  • 5-Ismn
  • AHR 4698
  • AHR-4698
  • BM 22-145
  • BM 22.145
  • BRN 5851319
  • CCRIS 1911
  • Conpin
  • Conpin Retardkaps
  • Corangin
  • Corangin SR
  • Duride
  • Edistol
  • EINECS 240-197-2
  • Elantan
  • Elantan Long
  • Elantan Retard
  • Epicordin
  • Etimonis
  • Fem-Mono
  • IHD
  • Imazin
  • Imdur
  • Imdur 60
  • Imdur Durules
  • Imodur
  • Imtrate
  • IS 5-MN
  • IS 5MN
  • Ismexin
  • ISMN
  • ISMN AbZ
  • ISMN AL
  • ISMN Apogepha
  • ISMN Atid
  • ISMN Basics
  • ISMN Heumann
  • ISMN Hexal
  • ISMN Lannacher
  • ISMN Stada
  • ISMO
  • Ismo-20
  • Ismox
  • Isomon
  • Isomonat
  • Isomonit
  • Isopen-20
  • Isosorbide 5-mononitrate
  • Isosorbide 5-nitrate
  • Isosorbide mononitrate
  • Isosorbidi mononitras
  • Isosorbidi mononitras [Latin]
  • Iturol
  • Medocor
  • Monicor
  • Monis
  • Monit 20
  • Monizid
  • Mono Corax
  • Mono Corax Retard
  • Mono Mack
  • Mono-Mack
  • Mono-Sanorania
  • Monoclair
  • Monocord 20
  • Monocord 40
  • Monocord 50 SR
  • Monodur Durules
  • Monoket
  • Monoket OD
  • Monoket Retard
  • Monolong
  • Monolong 40
  • Monolong 60
  • Mononit
  • Mononit 20
  • Mononit 40
  • Mononit Retard 50
  • Mononitrate d'isosorbide
  • Mononitrate d'isosorbide [French]
  • Mononitrato de isosorbida
  • Mononitrato de isosorbida [Spanish]
  • Monopront
  • MonoSigma
  • Monosorbitrate
  • Monosordil
  • Monotrate
  • Multitab
  • Nitex
  • Nitramin
  • Olicard
  • Olicardin
  • Orasorbil
  • Pentacard 20
  • Percorina
  • Pertil
  • Plodin
  • Promocard
  • Sigacora
  • Sorbimon
  • Titarane
  • Turimonit
  • UNII-LX1OH63030
  • Uniket
  • Vasdilat
  • vasotrate

Systematic Names

  • D-Glucitol, 1,4:3,6-dianhydro-, 5-nitrate
  • Furo(3,2-b)furan, D-glucitol deriv.
  • Glucitol, 1,4:3,6-dianhydro-, 5-nitrate, D-
  • Isosorbide mononitrate
  • Monisid

Superlist Names

  • Isosobide-5-mononitrate
  • Isosobide-5-mononitrate [UN3251] [Flammable solid]
  • UN3251

Registry Numbers

CAS Registry Number

  • 16051-77-7

FDA UNII

  • LX1OH63030

System Generated Number

  • 0016051777

Structure Descriptors

InChI

InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1

InChIKey

YWXYYJSYQOXTPL-SLPGGIOYSA-N

Smiles

O[C@H]1CO[C@@H]2[C@@H](CO[C@H]12)O[N+](=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1810mg/kg (1810mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 327, 1985.
mouse LD50 intraperitoneal 1810mg/kg (1810mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA		 Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 327, 1985.
mouse LD50 intravenous 1820mg/kg (1820mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 327, 1985.
mouse LD50 oral 1771mg/kg (1771mg/kg)   Bollettino Chimico Farmaceutico. Vol. 128, Pg. 74, 1989.
rat LD50 intraperitoneal 1760mg/kg (1760mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 327, 1985.
rat LD50 intraperitoneal 1760mg/kg (1760mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 327, 1985.
rat LD50 intravenous 1750mg/kg (1750mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)		 Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 327, 1985.
rat LD50 oral 2010mg/kg (2010mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

BEHAVIORAL: ATAXIA		 Oyo Yakuri. Pharmacometrics. Vol. 29, Pg. 327, 1985.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.15 (none)   EXP
Water Solubility 1.07E+05 mg/L 25 EST
Vapor Pressure 1.23E-04 mm Hg 25 EST
Henry's Law Constant 5.69E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.10E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.