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Substance Name: Importin
RN: 160576-62-5

Notes

  • A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.
  • Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
 
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Names and Synonyms

Name of Substance

  • Importin

MeSH Headings

  • alpha Karyopherins
  • Karyopherins

Synonyms

  • Importin 1
  • Importin 2
  • Importin-alpha

Systematic Name

  • Importin (Xenopus laevis isoform 1)

Registry Numbers

CAS Registry Number

  • 160576-62-5

System Generated Number

  • 0160576625